(Q34665985)

3 August 2017

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title

Oncogenic tyrosine kinases and the DNA-damage response (English)

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3 August 2017

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1

Tomasz Skorski

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PubMed ID

12044011

3 August 2017

language of work or name

English

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publication date

1 May 2002

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3 August 2017

Nature Reviews Cancer

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3 August 2017

2

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3 August 2017

351-360

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3 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrc799

3 August 2017

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cites work

Oncogenic kinase signalling

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Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

31 March 2020

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v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells.

31 March 2020

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TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome

31 March 2020

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

31 March 2020

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BCR-ABL down-regulates the DNA repair protein DNA-PKcs

31 March 2020

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Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal

31 March 2020

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Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids

31 March 2020

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The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

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Role of oncogenes in resistance and killing by cancer therapeutic agents.

31 March 2020

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Molecular mechanisms of drug resistance in tumours

31 March 2020

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Modelling the process of drug resistance

31 March 2020

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BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

31 March 2020

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From p63 to p53 across p73.

31 March 2020

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The molecular control of DNA damage-induced cell death

31 March 2020

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DNA repair: spot(light)s on chromatin.

31 March 2020

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Cellular responses to DNA damage

31 March 2020

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Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

31 March 2020

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

31 March 2020

1 reference

A structural view of mitochondria-mediated apoptosis

31 March 2020

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Rescue of arrested replication forks by homologous recombination

31 March 2020

1 reference

The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

1 reference

DNA double-strand breaks: signaling, repair and the cancer connection

31 March 2020

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Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

31 March 2020

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

31 March 2020

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Interrelationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression, and epidermal growth factor receptor level in non-small cell lung cancer cells.

31 March 2020

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The DNA damage response: putting checkpoints in perspective

31 March 2020

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Anticancer drug targets: cell cycle and checkpoint control.

31 March 2020

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

31 March 2020

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Cell cycle checkpoints: preventing an identity crisis

31 March 2020

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Dissociation of CDK2 from cyclin A in response to the topoisomerase II inhibitor etoposide in v-src-transformed but not normal NIH 3T3 cells

31 March 2020

1 reference

Early events in leukemogenesis in P190Bcr-abl transgenic mice

31 March 2020

1 reference

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

31 March 2020

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Apoptosis and cancer chemotherapy.

31 March 2020

1 reference

Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.

31 March 2020

1 reference

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

31 March 2020

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

31 March 2020

1 reference

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

31 March 2020

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The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.

31 March 2020

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The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

31 March 2020

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STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

1 reference

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

31 March 2020

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

31 March 2020

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Oxidative stress, DNA damage and the Y chromosome.

31 March 2020

1 reference

Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress

31 March 2020

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Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

31 March 2020

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TP53 abnormalities and genetic instability in breast cancer

31 March 2020

1 reference

Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase.

31 March 2020

1 reference

Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.

31 March 2020

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Eukaryotic DNA mismatch repair

31 March 2020

1 reference

Links between replication, recombination and genome instability in eukaryotes

31 March 2020

1 reference

Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

31 March 2020

1 reference

Renaturation rate studies of a single family of interspersed repeated sequences in human deoxyribonucleic acid

31 March 2020

1 reference

Genome-wide chromatin remodeling modulates the Alu heat shock response

31 March 2020

1 reference

Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation

31 March 2020

1 reference

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis

31 March 2020

1 reference

Chromosome breaks and genomic instability

31 March 2020

1 reference

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

31 March 2020

1 reference

p53 family genes: structural comparison, expression and mutation

31 March 2020

1 reference

Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

31 March 2020

1 reference

neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice

31 March 2020

1 reference

Pathways governing G1/S transition and their response to DNA damage

31 March 2020

1 reference

Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

31 March 2020

1 reference

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

31 March 2020

1 reference

High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia

31 March 2020

1 reference

In-frame deletions of BRCA1 may define critical functional domains

31 March 2020

1 reference

Brca1 controls homology-directed DNA repair

31 March 2020

1 reference

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

31 March 2020

1 reference

Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

31 March 2020

1 reference

Gene conversion (recombination) mediates expansions of CTG[middle dot]CAG repeats

31 March 2020

1 reference

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair.

31 March 2020

1 reference

RecA-mediated strand exchange traverses substitutional heterologies more easily than deletions or insertions

31 March 2020

1 reference

Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

31 March 2020

1 reference

RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors

31 March 2020

1 reference

Construction and characterization of a rad51rad52 double mutant as a host for YAC libraries

31 March 2020

1 reference

Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide

31 March 2020

1 reference

Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor beta-chain in BCR-ABL(+) human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibi

31 March 2020

1 reference

Chronic myelogenous leukemia

31 March 2020

1 reference

Improving the efficacy of antibody-based cancer therapies

31 March 2020

1 reference

Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoietic progenitor cells.

31 March 2020

1 reference

Rapid destruction of human Cdc25A in response to DNA damage

31 March 2020

1 reference

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

31 March 2020

1 reference

Regulation of the G2/M transition by p53.

31 March 2020

1 reference

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

31 March 2020

1 reference

31 March 2020

The Bcl-2 protein family

1 reference

BCL-2 family members and the mitochondria in apoptosis

31 March 2020

1 reference

Identification and purification of two distinct complexes containing the five RAD51 paralogs

31 March 2020

1 reference

Signal transduction pathways involved in BCR-ABL transformation

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC799

1 reference

PubMed ID

12044011

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

12044011