(Q34716318)

4 August 2017

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title

Cytotoxic T lymphocytes: all roads lead to death (English)

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4 August 2017

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Michele Barry

1

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PubMed ID

12093006

4 August 2017

R Chris Bleackley

series ordinal

2

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4 August 2017

1 June 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

401-409

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4 August 2017

6

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Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells

4 August 2017

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Mechanism of lymphocyte-mediated cytotoxicity

31 March 2020

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Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteinases and perforin

31 March 2020

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Cytotoxic T lymphocyte mediated lysis without release of serine esterase

31 March 2020

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Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

31 March 2020

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Effector lymphocytes in autoimmunity

31 March 2020

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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

31 March 2020

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Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

31 March 2020

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Significant role for Fas in the pathogenesis of autoimmune diabetes.

31 March 2020

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

31 March 2020

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31 March 2020

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CD95's deadly mission in the immune system

31 March 2020

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Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

31 March 2020

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

31 March 2020

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Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

31 March 2020

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

31 March 2020

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Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

31 March 2020

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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

31 March 2020

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Decreased tumor surveillance in perforin-deficient mice

31 March 2020

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Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes

31 March 2020

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Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

31 March 2020

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

31 March 2020

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

31 March 2020

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The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

31 March 2020

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

31 March 2020

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

31 March 2020

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

31 March 2020

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Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

31 March 2020

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Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

31 March 2020

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Definition and redesign of the extended substrate specificity of granzyme B.

31 March 2020

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

31 March 2020

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Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue

31 March 2020

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The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

31 March 2020

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

31 March 2020

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

31 March 2020

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Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

31 March 2020

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Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

31 March 2020

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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

31 March 2020

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

31 March 2020

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Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

31 March 2020

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Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

31 March 2020

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Mitochondrial control of cell death

31 March 2020

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

31 March 2020

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Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

31 March 2020

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

31 March 2020

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

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Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

31 March 2020

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

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Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells

31 March 2020

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Breaking the mitochondrial barrier

31 March 2020

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The mitochondrion in apoptosis: how Pandora's box opens

31 March 2020

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

31 March 2020

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

31 March 2020

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

31 March 2020

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

31 March 2020

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Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

31 March 2020

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Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

31 March 2020

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Two CD95 (APO-1/Fas) signaling pathways

31 March 2020

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

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Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

31 March 2020

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

31 March 2020

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Endonuclease G is an apoptotic DNase when released from mitochondria

31 March 2020

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

31 March 2020

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Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

31 March 2020

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DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

31 March 2020

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Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

31 March 2020

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Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

31 March 2020

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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

31 March 2020

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Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells

31 March 2020

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

31 March 2020

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Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes.

31 March 2020

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

31 March 2020

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Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

31 March 2020

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In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

31 March 2020

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

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Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

31 March 2020

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Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.

31 March 2020

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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

31 March 2020

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Viral subversion of the immune system

31 March 2020

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Immune evasion by human cytomegalovirus: lessons in immunology and cell biology

31 March 2020

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31 March 2020

Viruses and Apoptosis

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Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

31 March 2020

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Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

31 March 2020

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M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes

31 March 2020

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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

31 March 2020

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Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore

31 March 2020

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Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death

31 March 2020

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Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells

31 March 2020

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Granulysin: a lethal weapon of cytolytic T cells

31 March 2020

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An antimicrobial activity of cytolytic T cells mediated by granulysin

31 March 2020

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CTL-mediated killing of intracellular Mycobacterium tuberculosis is independent of target cell nuclear apoptosis

31 March 2020

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Granulysin, a T cell product, kills bacteria by altering membrane permeability

31 March 2020

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A distinct pathway of cell-mediated apoptosis initiated by granulysin

31 March 2020

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A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

31 March 2020

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Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

31 March 2020

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

31 March 2020

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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

31 March 2020

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Lymphocyte-mediated cytotoxicity.

31 March 2020

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31 March 2020

Identifiers

0 references

1 reference

PubMed ID

12093006