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NF-kappa B: arresting a major culprit in cancer
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
NF-kappa B: arresting a major culprit in cancer
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
main subject
NF-κB
0 references
author name string
Burkhard Haefner
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
publication date
1 June 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
published in
Drug Discovery Today
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
volume
7
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
page(s)
653-663
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
issue
12
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
cites work
NF-kappaB in cancer: from innocent bystander to major culprit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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Chronic immune activation and inflammation as the cause of malignancy
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Crossref
reference URL
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7 January 2021
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Inflammation and cancer: back to Virchow?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
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Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Paradoxical effects of tumour necrosis factor in experimental ovarian cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
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NSAIDs and gastrointestinal cancer prevention
1 reference
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Crossref
reference URL
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7 January 2021
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant rel/nfkb genes and activity in human cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
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Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into the role of nuclear factor-kB in cell growth regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour necrosis factor and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coley's toxins, tumor necrosis factor and cancer research: a historical perspective
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An endotoxin-induced serum factor that causes necrosis of tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of NF-κB in p53-mediated programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
NF-κB-mediated Induction ofmdr1bExpression by Insulin in Rat Hepatoma Cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
New-age drug meets resistance
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The role of cytokines in cancer cachexia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The TRAIL to an anti-cancer agent.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The use of TNF family ligands and receptors and agents which modify their interaction as therapeutic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The potential of TRAIL for cancer chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production by the introduction of a super-repressor form of inhibitor of nuclear factor kappaBalpha complementary DNA into immortalized human salivary gland acinar cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of GSK3beta reveals a primed phosphorylation mechanism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
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The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The renaissance of GSK3
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sulindac inhibits activation of the NF-kappaB pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thalidomide: a novel template for anticancer drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasome regulation of activation-induced T cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappa B as a therapeutic target in multiple myeloma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1359-6446(02)02309-7
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
PubMed ID
12110242
1 reference
stated in
Europe PubMed Central
PubMed ID
12110242
retrieved
4 August 2017
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