(Q34742798)

Efficacy in drug receptor theory: outdated concept or under-valued tool?

31 March 2020

1 reference

Agonist efficacy and allosteric models of receptor action.

31 March 2020

1 reference

THE BINDING POTENTIAL, A NEGLECTED LINKAGE CONCEPT.

31 March 2020

1 reference

Ligand binding and internal equilibiums in proteins

31 March 2020

1 reference

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

31 March 2020

1 reference

G proteins: transducers of receptor-generated signals

31 March 2020

1 reference

How receptors talk to trimeric G proteins

31 March 2020

1 reference

The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists.

31 March 2020

1 reference

The elusive nature of intrinsic efficacy.

31 March 2020

1 reference

Conformational substates in proteins

31 March 2020

1 reference

The Energy Landscapes and Motions of Proteins

31 March 2020

1 reference

Is the slow exchange core the protein folding core?

31 March 2020

1 reference

Hydrogen exchange and the dynamic structure of proteins

31 March 2020

1 reference

Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

31 March 2020

1 reference

Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease

31 March 2020

1 reference

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble

31 March 2020

1 reference

Protein folding intermediates: native-state hydrogen exchange

31 March 2020

1 reference

Determinants of protein hydrogen exchange studied in equine cytochrome c.

31 March 2020

1 reference

Experimental study of the protein folding landscape: unfolding reactions in cytochrome c.

31 March 2020

1 reference

Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif

31 March 2020

1 reference

Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling

31 March 2020

1 reference

The second intracellular loop of the alpha2-adrenergic receptors determines subtype-specific coupling to cAMP production

31 March 2020

1 reference

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

31 March 2020

1 reference

G(i) activator region of alpha(2A)-adrenergic receptors: distinct basic residues mediate G(i) versus G(s) activation

31 March 2020

1 reference

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

31 March 2020

1 reference

RAMPs: accessory proteins for seven transmembrane domain receptors

31 March 2020

1 reference

Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor

31 March 2020

1 reference

Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.

31 March 2020

1 reference

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

31 March 2020

1 reference

Cloning and characterization of MUPP1, a novel PDZ domain protein

31 March 2020

1 reference

Heptahelical receptor signaling: beyond the G protein paradigm.

31 March 2020

1 reference

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

31 March 2020

1 reference

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

31 March 2020

1 reference

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

31 March 2020

1 reference

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

31 March 2020

1 reference

A study of the desensitization produced by acetylcholine at the motor end-plate

31 March 2020

1 reference

Interaction at End-Plate Receptors between Different Choline Derivatives

31 March 2020

1 reference

Imprecision in presentation of binding studies

31 March 2020

1 reference

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

31 March 2020

1 reference

Inhibition of Lysosomal Plasminogen Activator Activity in Experimental Shock

31 March 2020

1 reference

The two-state model of receptor activation

31 March 2020

1 reference

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

31 March 2020

1 reference

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

31 March 2020

1 reference

Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy.

31 March 2020

1 reference

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

31 March 2020

1 reference

The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection

31 March 2020

1 reference

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

31 March 2020

1 reference

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

31 March 2020

1 reference

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

31 March 2020

1 reference

31 March 2020

1 reference

Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state

31 March 2020

1 reference

Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.

31 March 2020

1 reference

Mu opioid receptor phosphorylation, desensitization, and ligand efficacy

31 March 2020

1 reference

Differential opioid agonist regulation of the mouse mu opioid receptor

31 March 2020

1 reference

Morphine activates opioid receptors without causing their rapid internalization

31 March 2020

1 reference

High constitutive activity of native H3 receptors regulates histamine neurons in brain.

31 March 2020

1 reference

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

31 March 2020

1 reference

Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor up-regulation in vivo

31 March 2020

1 reference

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

31 March 2020

1 reference

Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation

31 March 2020

1 reference

Constitutive receptor systems for drug discovery

31 March 2020

1 reference

Creation and functional screening of a multi-use peptide library

31 March 2020

1 reference

Tools for investigating functional interactions between ligands and G-protein-coupled receptors

31 March 2020

1 reference

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

31 March 2020

1 reference

Can allosteric regulation be predicted from structure?

31 March 2020

1 reference

Energetics of Ligand Binding to Proteins

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Hydrogen Exchange in Proteins

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Recombinant human CXC-chemokine receptor-4 in melanophores are linked to Gi protein: seven transmembrane coreceptors for human immunodeficiency virus entry into cells

1 reference