(Q34743204)

4 August 2017

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title

Nucleic-acid therapeutics: basic principles and recent applications (English)

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4 August 2017

Joanna B Opalinska

1

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PubMed ID

12120257

4 August 2017

Alan M Gewirtz

series ordinal

2

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4 August 2017

1 July 2002

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Nature Reviews Drug Discovery

4 August 2017

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4 August 2017

1

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4 August 2017

503-514

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4 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd837

4 August 2017

0 references

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Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

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Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

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Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death.

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides

31 March 2020

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CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

31 March 2020

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Uptake of oligonucleotides by keratinocytes

31 March 2020

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Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides

31 March 2020

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Novel cationic amphiphiles as delivery agents for antisense oligonucleotides

31 March 2020

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Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia

31 March 2020

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Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.

31 March 2020

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Molecular and cellular characterization of baboon C-Raf as a target for antiproliferative effects of antisense oligonucleotides.

31 March 2020

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Dislodgment and accelerated degradation of Ras.

31 March 2020

1 reference

31 March 2020

Does antisense exist?

1 reference

Fomivirsen - a phosphorothioate oligonucleotide for the treatment of CMV retinitis

31 March 2020

1 reference

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)

31 March 2020

1 reference

Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

31 March 2020

1 reference

Degradation of mRNA in eukaryotes

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD837

1 reference

4 August 2017

1 reference

PubMed ID

12120257