(Q34808276)

4 August 2017

1 reference

title

The significance of QT interval in drug development (English)

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4 August 2017

Rashmi R Shah

1

1 reference

4 August 2017

language of work or name

English

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publication date

1 August 2002

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British Journal of Clinical Pharmacology

4 August 2017

published in

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4 August 2017

volume

54

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4 August 2017

issue

2

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4 August 2017

page(s)

188-202

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Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus

4 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density

8 July 2018

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8 July 2018

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A minK-HERG complex regulates the cardiac potassium current I(Kr)

8 July 2018

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Combined use of astemizole and ketoconazole resulting in torsade de pointes

8 July 2018

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Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole

8 July 2018

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8 July 2018

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Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers

8 July 2018

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8 July 2018

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Use of terfenadine and contraindicated drugs

8 July 2018

1 reference

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Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

8 July 2018

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Clinical safety profile of sotalol in the treatment of arrhythmias

8 July 2018

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Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart

8 July 2018

1 reference

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Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

8 July 2018

1 reference

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

8 July 2018

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

8 July 2018

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Torsade de pointes due to quinidine: observations in 31 patients

8 July 2018

1 reference

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Sotalol, hypokalaemia, syncope, and torsade de pointes

8 July 2018

1 reference

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8 July 2018

1 reference

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Prolonged QT and hypertrophic cardiomyopathy in two families with 10 sudden deaths.

8 July 2018

1 reference

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8 July 2018

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8 July 2018

1 reference

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Torsade de pointes after astemizole overdose.

8 July 2018

1 reference

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Controlled study of haloperidol, pimozide and placebo for the treatment of Gilles de la Tourette's syndrome

8 July 2018

1 reference

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Cardiotoxic effect with convulsions in terfenadine overdose

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874403

Torsades de pointes occurring in association with terfenadine use

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874403

Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874403

Drug-induced QT prolongation in women during the menstrual cycle

8 July 2018

1 reference

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Prolongation of the QT interval and the sudden infant death syndrome.

21 January 2018

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Abnormalities of the QT interval in primary disorders of autonomic failure.

21 January 2018

1 reference

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Potassium channel down-regulation in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01627.X

Exploring the hidden danger of noncardiac drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01627.X

The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01627.X

Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01627.X

Problems of heart rate correction in assessment of drug-induced QT interval prolongation.

21 January 2018

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The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods

21 January 2018

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12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

1 reference

12 December 2020

Pharmacokinetics of sertindole and dehydrosertindole in volunteers with normal or impaired renal function

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12 December 2020

QT interval prolongation as predictor of sudden death in patients with myocardial infarction

1 reference

12 December 2020

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability

1 reference

12 December 2020

Variability of the QT measurement in healthy men, with implications for selection of an abnormal QT value to predict drug toxicity and proarrhythmia

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12 December 2020

Low penetrance in the long-QT syndrome: clinical impact

1 reference

12 December 2020

The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine

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12 December 2020

[Prolonged QTc intervals in Parkinson's disease--relation to sudden death and autonomic dysfunction]

1 reference

12 December 2020

Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin

1 reference

12 December 2020

Effect of single ascending, supratherapeutic doses of sparfloxacin on cardiac repolarization (QTc interval)

1 reference

12 December 2020

Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis

1 reference

12 December 2020

Stereoselective cardiotoxic effects of terodiline

1 reference

12 December 2020

Altered ventricular repolarization during hypoglycaemia in patients with diabetes

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

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12 December 2020

ECG changes during haloperidol and pimozide treatment of Tourette's disorder

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12 December 2020

Contraindicated use of cisapride: impact of food and drug administration regulatory action

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12 December 2020

Severe cardiac arrythmia on cisapride

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12 December 2020

The cardiac pharmacodynamics of therapeutic doses of sparfloxacin

1 reference

12 December 2020

Molecular genetics of the long QT syndrome: two novel mutations of the KVLQT1 gene and phenotypic expression of the mutant gene in a large kindred

1 reference

12 December 2020

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans

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12 December 2020

Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

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12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

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12 December 2020

[Torsade de pointes. Apropos of 54 cases]

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12 December 2020

Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors

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12 December 2020

Prolonged QT interval in hypertrophic and dilated cardiomyopathy in children

1 reference

12 December 2020

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

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12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

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12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

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12 December 2020

QT interval prolongation and mortality in type 1 diabetic patients: a 5-year cohort prospective study. Neuropathy Study Group of the Italian Society of the Study of Diabetes, Piemonte Affiliate

1 reference

12 December 2020

10.1046/J.1365-2125.2002.01627.X

Identifiers

DOI

1 reference

4 August 2017

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4 August 2017

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