(Q34816596)

4 August 2017

title

Development of a concise synthesis of (-)-oseltamivir (Tamiflu) (English)

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4 August 2017

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1

Barry M Trost

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4 August 2017

Ting Zhang

2

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4 August 2017

language of work or name

English

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publication date

1 March 2011

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Chemistry—A European Journal

4 August 2017

published in

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4 August 2017

volume

17

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4 August 2017

issue

13

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4 August 2017

page(s)

3630-3643

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Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza

4 August 2017

cites work

1 reference

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Understanding the differential performance of Rh2(esp)2 as a catalyst for C-H amination

8 July 2018

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High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations

8 July 2018

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A Concise Synthesis of (−)-Oseltamivir

8 July 2018

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Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.

8 July 2018

1 reference

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A practical synthesis of (-)-oseltamivir

8 July 2018

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Catalytic intermolecular amination of C-H bonds: method development and mechanistic insights

8 July 2018

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Second Generation Catalytic Asymmetric Synthesis of Tamiflu: Allylic Substitution Route

8 July 2018

1 reference

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Tamiflu: the supply problem

8 July 2018

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De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso -Aziridines with TMSN 3

8 July 2018

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A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1,3-butadiene and acrylic acid

8 July 2018

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New class of nucleophiles for palladium-catalyzed asymmetric allylic alkylation. Total synthesis of agelastatin A.

8 July 2018

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Palladium-catalyzed asymmetric allylic alkylation of meso- and dl-1,2-divinylethylene carbonate

8 July 2018

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Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

8 July 2018

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Practical Total Synthesis of the Anti-Influenza Drug GS-4104

8 July 2018

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The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu ® ): A Challenge for Synthesis & Process Research

21 January 2018

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Efficient access to oseltamivir phosphate (Tamiflu) via the O-trimesylate of shikimic acid ethyl ester.

21 January 2018

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An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir.

21 January 2018

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A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type reaction.

21 January 2018

1 reference

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Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Use of the Diels-Alder adduct of pyrrole in organic synthesis. Formal racemic synthesis of Tamiflu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Organocatalytic Michael addition of aldehydes to protected 2-amino-1-nitroethenes: the practical syntheses of oseltamivir (Tamiflu) and substituted 3-aminopyrrolidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Asymmetric Alkylation of Nitroalkanes We thank the National Science Foundation and the National Institutes of Health (NIH), General Medical Sciences, for their generous support of our programs. Rhône-Poulenc graciously provided a postdoctoral fellow

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Palladium-catalyzed DYKAT of vinyl epoxides: enantioselective total synthesis and assignment of the configuration of (+)-Broussonetine G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Advances in Nitrogen Transfer Reactions Involving Aziridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Base promoted isomerization of aziridinyl ethers: a new access to alpha- and beta-amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Aziridines versus vinyl carbamates from the direct amination of electron-withdrawing group-substituted trifluoromethyl enoates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Diastereoselective aziridination of chiral alpha-carbonyl enoates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Nitrene Transfer Reactions Catalyzed by Gold Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

A unique and highly efficient method for catalytic olefin aziridination

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201003454

Expanding the scope of C-H amination through catalyst design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Rh(II)-catalyzed intermolecular oxidative sulfamidation of aldehydes: a mild efficient synthesis of N-sulfonylcarboxamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Asymmetric induction in allylic alkylations of 3-(acyloxy)cycloalkenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Asymmetric synthesis of N-aryl aziridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Application of Chiral Mixed Phosphorus/Sulfur Ligands to Palladium-Catalyzed Allylic Substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201003454

Palladium-catalyzed DYKAT of butadiene monoepoxide: enantioselective total synthesis of (+)-DMDP, (-)-bulgecinine, and (+)-broussonetine G

21 January 2018

1 reference

12 December 2020

Ring-closing metathesis-based synthesis of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy- cyclohex-1-ene-carboxylic acid ethyl ester: a functionalized cycloalkene skeleton of GS4104

1 reference

12 December 2020

Aza-Michael addition of nosyloxycarbamates to 2-(trifluoromethyl)acrylates

1 reference

12 December 2020

A convergent Pd-catalyzed asymmetric allylic alkylation of dl- and meso-divinylethylene carbonate: enantioselective synthesis of (+)-australine hydrochloride and formal synthesis of isoaltholactone

1 reference

12 December 2020

Dicobalt octacarbonyl promoted rearrangement of 4-isoxazolines to acylaziridines: dramatic rate acceleration with very high substrate tolerance

1 reference

12 December 2020

Synthesis of 7-Epi +-FR900482: an epimer of comparable anti-cancer activity

1 reference

12 December 2020

Efficient aziridination of olefins catalyzed by a unique disilver(I) compound

1 reference

12 December 2020

Iron(III) porphyrin catalyzed aziridination of alkenes with bromamine-T as nitrene source

1 reference

12 December 2020

Organocatalytic asymmetric 1,6-additions of beta-ketoesters and glycine imine

1 reference

12 December 2020

Iodine catalyzed one-pot diamination of glycals with chloramine-T: a new approach to 2-amino-beta-glycosylamines for applications in N-glycopeptide synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1002/CHEM.201003454

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4 August 2017

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4 August 2017

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