(Q34858737)

4 August 2017

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title

New regulators of NF-kappaB in inflammation (English)

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4 August 2017

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Sankar Ghosh

1

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PubMed ID

18927578

4 August 2017

Matthew S Hayden

series ordinal

2

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4 August 2017

1 November 2008

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Nature Reviews Immunology

4 August 2017

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4 August 2017

8

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4 August 2017

837-848

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4 August 2017

11

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NF-kappaB and the immune response

4 August 2017

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Gene-specific control of inflammation by TLR-induced chromatin modifications

31 March 2020

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Deubiquitylation and regulation of the immune response

31 March 2020

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

31 March 2020

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Immunity by ubiquitylation: a reversible process of modification

31 March 2020

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Shaping the nuclear action of NF-kappaB

31 March 2020

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Transcriptional regulation via the NF-kappaB signaling module.

31 March 2020

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Shared principles in NF-kappaB signaling

31 March 2020

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When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

31 March 2020

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Regulation and function of IKK and IKK-related kinases

31 March 2020

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The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

31 March 2020

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

31 March 2020

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Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).

31 March 2020

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

31 March 2020

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

31 March 2020

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SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

31 March 2020

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IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.

31 March 2020

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Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

31 March 2020

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Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

31 March 2020

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Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

31 March 2020

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p53 regulates the expression of the tumor suppressor gene maspin

31 March 2020

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The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

31 March 2020

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The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner

31 March 2020

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Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo

31 March 2020

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Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA

31 March 2020

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The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers

31 March 2020

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

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The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition

31 March 2020

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p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

31 March 2020

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BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages

31 March 2020

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Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade

31 March 2020

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IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

31 March 2020

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Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice

31 March 2020

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Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization

31 March 2020

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Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

31 March 2020

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Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein

31 March 2020

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Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor

31 March 2020

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The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

31 March 2020

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IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.

31 March 2020

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Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response

31 March 2020

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Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption

31 March 2020

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation

31 March 2020

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RelB cellular regulation and transcriptional activity are regulated by p100.

31 March 2020

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Stabilization of RelB requires multidomain interactions with p100/p52.

31 March 2020

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Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.

31 March 2020

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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

31 March 2020

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Modulation of NF-kappaB activity by exchange of dimers.

31 March 2020

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Induction of RelB participates in endotoxin tolerance

31 March 2020

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Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance

31 March 2020

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A fourth IkappaB protein within the NF-kappaB signaling module

31 March 2020

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Regulation of naive T cell function by the NF-kappaB2 pathway

31 March 2020

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Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.

31 March 2020

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Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

31 March 2020

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p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

31 March 2020

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

31 March 2020

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Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

31 March 2020

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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

31 March 2020

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MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation

31 March 2020

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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

31 March 2020

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Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

31 March 2020

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Distinct cellular functions of MK2.

31 March 2020

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Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

31 March 2020

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

31 March 2020

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Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response

31 March 2020

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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2020

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SOCS-1 participates in negative regulation of LPS responses

31 March 2020

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

31 March 2020

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

31 March 2020

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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

31 March 2020

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COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

31 March 2020

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PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

31 March 2020

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Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A

31 March 2020

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Nuclear actin and actin-related proteins in chromatin dynamics

31 March 2020

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Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells

31 March 2020

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Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress

31 March 2020

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Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression

31 March 2020

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PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.

31 March 2020

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Negative regulation of NF-kappaB signaling by PIAS1.

31 March 2020

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Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life

31 March 2020

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Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation

31 March 2020

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Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

31 March 2020

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PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

31 March 2020

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Possible new role for NF-kappaB in the resolution of inflammation.

31 March 2020

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The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

31 March 2020

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Epithelial NEMO links innate immunity to chronic intestinal inflammation

31 March 2020

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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

31 March 2020

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

31 March 2020

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2423

1 reference

4 August 2017

1 reference

PubMed ID

18927578