(Q34931863)

5 August 2017

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title

Functional significance of the perforin/granzyme cell death pathway (English)

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5 August 2017

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Joseph A Trapani

1

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Mark J. Smyth

object named as

Mark J Smyth

series ordinal

2

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publication date

1 October 2002

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Nature Reviews Immunology

5 August 2017

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5 August 2017

2

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5 August 2017

735-747

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5 August 2017

10

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Granzymes: exogenous proteinases that induce target cell apoptosis.

5 August 2017

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

31 March 2020

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Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

31 March 2020

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31 March 2020

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Role of Fas-mediated cell death in the regulation of immune responses

31 March 2020

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Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

31 March 2020

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L is for lytic granules: lysosomes that kill

31 March 2020

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NK cells and NKT cells in innate defense against viral infections

31 March 2020

1 reference

Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells

31 March 2020

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Immunobiology of dendritic cells

31 March 2020

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NKT cells: facts, functions and fallacies.

31 March 2020

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Cytotoxic T lymphocytes: all roads lead to death

31 March 2020

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

31 March 2020

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

31 March 2020

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

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Long-range disruption of gene expression by a selectable marker cassette

31 March 2020

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

31 March 2020

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

31 March 2020

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Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

31 March 2020

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CTL granules: evolution of vesicles essential for combating virus infections

31 March 2020

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Cytolytic pathways in haematopoietic stem-cell transplantation

31 March 2020

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Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

31 March 2020

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

31 March 2020

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Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

31 March 2020

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Papillon-Lefèvre syndrome: mutations and polymorphisms in the cathepsin C gene

31 March 2020

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

31 March 2020

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Perforin-mediated myocardial damage in acute myocarditis

31 March 2020

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

31 March 2020

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Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

31 March 2020

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

31 March 2020

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

31 March 2020

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

31 March 2020

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Structure, function and expression of murine and human perforin 1 (P1).

31 March 2020

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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

31 March 2020

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Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

31 March 2020

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Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

31 March 2020

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An antimicrobial activity of cytolytic T cells mediated by granulysin

31 March 2020

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Homeostatic regulation of CD8+ T cells by perforin

31 March 2020

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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

31 March 2020

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Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

31 March 2020

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Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

31 March 2020

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A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells

31 March 2020

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Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice

31 March 2020

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Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

31 March 2020

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

31 March 2020

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Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

31 March 2020

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Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin

31 March 2020

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T cell-mediated tumor rejection displays diverse dependence upon perforin and IFN-gamma mechanisms that cannot be predicted from in vitro T cell characteristics.

31 March 2020

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Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection

31 March 2020

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Differential tumor surveillance by natural killer (NK) and NKT cells.

31 March 2020

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

31 March 2020

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Regulation of cutaneous malignancy by gammadelta T cells

31 March 2020

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Decreased tumor surveillance in perforin-deficient mice

31 March 2020

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Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

31 March 2020

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Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease

31 March 2020

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Perforin- and Fas-dependent mechanisms of natural killer cell-mediated rejection of incompatible bone marrow cell grafts

31 March 2020

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Epstein-Barr virus-specific T-cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation

31 March 2020

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Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo

31 March 2020

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Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: implications for adaptive immunotherapy.

31 March 2020

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Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity

31 March 2020

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Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus

31 March 2020

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Influence of effector molecules on the CD8(+) T cell response to infection

31 March 2020

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Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis

31 March 2020

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Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members

31 March 2020

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

31 March 2020

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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

31 March 2020

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A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.

31 March 2020

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Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

31 March 2020

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Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice.

31 March 2020

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Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells

31 March 2020

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The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

31 March 2020

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A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

31 March 2020

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A distinct pathway of cell-mediated apoptosis initiated by granulysin

31 March 2020

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Perforin is required for primary immunity to Histoplasma capsulatum

31 March 2020

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Trypanosoma cruzi: roles for perforin-dependent and perforin-independent immune mechanisms in acute resistance.

31 March 2020

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Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection

31 March 2020

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Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection

31 March 2020

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Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

31 March 2020

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Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice

31 March 2020

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Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice

31 March 2020

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Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

31 March 2020

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Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection

31 March 2020

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T cells compete for access to antigen-bearing antigen-presenting cells

31 March 2020

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T cells down-modulate peptide-MHC complexes on APCs in vivo.

31 March 2020

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

31 March 2020

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Virally infected hepatocytes are resistant to perforin-dependent CTL effector mechanisms

31 March 2020

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IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity In vivo

31 March 2020

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A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression

31 March 2020

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Immune evasion by tumours: involvement of the CD95 (APO-1/Fas) system and its clinical implications

31 March 2020

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Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

31 March 2020

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Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death

31 March 2020

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HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.

31 March 2020

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Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.

31 March 2020

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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

31 March 2020

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Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells

31 March 2020

1 reference

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

31 March 2020

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Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

31 March 2020

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

31 March 2020

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

31 March 2020

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

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Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

31 March 2020

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

31 March 2020

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Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

31 March 2020

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

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Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

31 March 2020

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

31 March 2020

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A molecular genetic linkage map of mouse chromosome 19, including thelpr, Ly-44, andTdt genes

31 March 2020

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Immune function in mice lacking the perforin gene

31 March 2020

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Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI911

1 reference

5 August 2017

1 reference

PubMed ID

12360212