(Q35013204)

5 August 2017

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title

Pancreatic cancer biology and genetics (English)

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5 August 2017

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1

Nabeel Bardeesy

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Ronald A. DePinho

series ordinal

2

object named as

Ronald A DePinho

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PubMed ID

12459728

5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

Nature Reviews Cancer

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5 August 2017

2

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5 August 2017

897-909

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5 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc949

5 August 2017

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cites work

The National Cancer Data Base report on pancreatic cancer

1 reference

31 March 2020

1 reference

31 March 2020

Focus on pancreas cancer

1 reference

A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34

31 March 2020

1 reference

Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group

31 March 2020

1 reference

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

31 March 2020

1 reference

Lessons from hereditary colorectal cancer

31 March 2020

1 reference

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

31 March 2020

1 reference

Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression

31 March 2020

1 reference

Genetic progression and divergence in pancreatic carcinoma

31 March 2020

1 reference

Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis

31 March 2020

1 reference

Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma

31 March 2020

1 reference

Understanding Ras: 'it ain't over 'til it's over'.

31 March 2020

1 reference

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

31 March 2020

1 reference

Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer

31 March 2020

1 reference

Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors

31 March 2020

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An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells

31 March 2020

1 reference

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

31 March 2020

1 reference

Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms

31 March 2020

1 reference

Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum

31 March 2020

1 reference

Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice

31 March 2020

1 reference

Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

31 March 2020

1 reference

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations

31 March 2020

1 reference

Genotype-Phenotype Relationships in U.S. Melanoma-Prone Families With CDKN2A and CDK4 Mutations

31 March 2020

1 reference

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome

31 March 2020

1 reference

High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families

31 March 2020

1 reference

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma

31 March 2020

1 reference

Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations

31 March 2020

1 reference

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

1 reference

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

1 reference

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

31 March 2020

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Cellular senescence: mitotic clock or culture shock?

31 March 2020

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

31 March 2020

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

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Senescence of human fibroblasts induced by oncogenic Raf.

31 March 2020

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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers

31 March 2020

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

31 March 2020

1 reference

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

31 March 2020

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

31 March 2020

1 reference

The INK4A/ARF locus and its two gene products

31 March 2020

1 reference

Connecting chromosomes, crisis, and cancer

31 March 2020

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Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations.

31 March 2020

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

31 March 2020

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

1 reference

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

31 March 2020

1 reference

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

31 March 2020

1 reference

Cancer susceptibility and the functions of BRCA1 and BRCA2

31 March 2020

1 reference

BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications

31 March 2020

1 reference

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

31 March 2020

1 reference

Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome.

31 March 2020

1 reference

Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer

31 March 2020

1 reference

Mutations predisposing to hereditary nonpolyposis colorectal cancer

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: a family study

1 reference

Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity

31 March 2020

1 reference

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

31 March 2020

1 reference

TGFbeta signaling in growth control, cancer, and heritable disorders

31 March 2020

1 reference

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

31 March 2020

1 reference

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

31 March 2020

1 reference

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

31 March 2020

1 reference

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

31 March 2020

1 reference

The role of Langerhans islets in pancreatic ductal adenocarcinoma

31 March 2020

1 reference

Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.

31 March 2020

1 reference

Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

31 March 2020

1 reference

Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats

31 March 2020

1 reference

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

31 March 2020

1 reference

How cells change their phenotype

31 March 2020

1 reference

The evolving concept of a stem cell: entity or function?

31 March 2020

1 reference

31 March 2020

Pancreatic stem cells

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The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

31 March 2020

1 reference

p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas

31 March 2020

1 reference

PDX-1 and Msx-2 expression in the regenerating and developing pancreas

31 March 2020

1 reference

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro

31 March 2020

1 reference

Epidermal growth factor receptor and Ink4a/Arf

31 March 2020

1 reference

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

31 March 2020

1 reference

Putting tumours in context

31 March 2020

1 reference

Cancer modeling in the modern era: progress and challenges

31 March 2020

1 reference

Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.

31 March 2020

1 reference

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice.

31 March 2020

1 reference

Pancreatic tumor pathogenesis reflects the causative genetic lesion

31 March 2020

1 reference

Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver

31 March 2020

1 reference

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia

31 March 2020

1 reference

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

31 March 2020

1 reference

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

31 March 2020

1 reference

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

31 March 2020

1 reference

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

31 March 2020

1 reference

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

31 March 2020

1 reference

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

31 March 2020

1 reference

Conditional mouse models of sporadic cancer

31 March 2020

1 reference

Essential role for oncogenic Ras in tumour maintenance

31 March 2020

1 reference

5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue

31 March 2020

1 reference

Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging

31 March 2020

1 reference

Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer

31 March 2020

1 reference

COX selectivity and animal models for colon cancer

31 March 2020

1 reference

DNA microarrays in clinical oncology

31 March 2020

1 reference

Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

31 March 2020

1 reference

Intercellular signals regulating pancreas development and function

31 March 2020

1 reference

Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines

31 March 2020

1 reference

Pancreatic organogenesis--developmental mechanisms and implications for therapy

31 March 2020

1 reference

Notochord repression of endodermal Sonic hedgehog permits pancreas development

31 March 2020

1 reference

Vertebrate endoderm development

31 March 2020

1 reference

Molecular basis of transdifferentiation of pancreas to liver

31 March 2020

1 reference

Very high risk of cancer in familial Peutz-Jeghers syndrome

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC949

1 reference

5 August 2017

1 reference

PubMed ID

12459728