(Q35026390)

5 August 2017

1 reference

title

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability (English)

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Nijmegen breakage syndrome

5 August 2017

1 reference

1 reference

Hiroshi Tauchi

1

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5 August 2017

Shinya Matsuura

2

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5 August 2017

Junya Kobayashi

3

1 reference

5 August 2017

Shuichi Sakamoto

4

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5 August 2017

Kenshi Komatsu

5

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5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

21

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5 August 2017

8967-8980

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5 August 2017

58

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206136

5 August 2017

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cites work

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Chk2 activation dependence on Nbs1 after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Determination of the frequency of the common 657Del5 Nijmegen breakage syndrome mutation in the German population: no association with risk of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Fine localization of the Nijmegen breakage syndrome gene to 8q21: evidence for a common founder haplotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The yeast Xrs2 complex functions in S phase checkpoint regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The plant Rad50-Mre11 protein complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Protection of mammalian telomeres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA double strand break repair and chromosomal translocation: lessons from animal models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Human MRE11 is inactivated in mismatch repair-deficient cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The many interfaces of Mre11

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Ataxia without telangiectasia masquerading as benign hereditary chorea

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Lack of correlation between radiosensitivity and inhibition of DNA synthesis in hybrids (A-T x HeLa)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Murine scid cells complement ataxia-telangiectasia cells and show a normal post-irradiation response of DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Complementation of chromosomal aberrations in AT/NBS hybrids: inadequacy of RDS as an endpoint in complementation studies with immortal NBS cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Recombinational DNA double-strand breaks in mice precede synapsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Positional cloning of the gene for Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Accelerated telomere shortening in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA repair: spot(light)s on chromatin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Radiosensitivity of ataxia telangiectasia and Nijmegen breakage syndrome homozygotes and heterozygotes as determined by three-color FISH chromosome painting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Radiosensitivity in ataxia-telangiectasia: a new explanation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Mre11 complex and ATM: collaborating to navigate S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Histone H2A variants H2AX and H2AZ

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

An increased risk for malignant neoplasms in heterozygotes for a syndrome of microcephaly, normal intelligence, growth retardation, remarkable facies, immunodeficiency and chromosomal instability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

No evidence for deletions of the NBS1 gene in lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The Rad51 paralog Rad51B promotes homologous recombinational repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657del5, in three Slav populations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Decreased immunoglobulin class switching in Nijmegen Breakage syndrome due to the DNA repair defect.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

A new chromosomal instability disorder: the Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

A murine model of Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206136

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206136

1 reference

5 August 2017

1 reference