(Q35036600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

1 reference

title

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

0 references

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Peter J. Ratcliffe

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Christopher William Pugh

series ordinal

1

1 reference

5 August 2017

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

Seminars in Cancer Biology

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

83-89

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

The VHL tumour-suppressor gene paradigm

16 December 2019

cites work

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7 January 2021

Identification of the von Hippel-Lindau disease tumor suppressor gene

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7 January 2021

Antioncogenes and human cancer

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7 January 2021

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

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7 January 2021

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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7 January 2021

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

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7 January 2021

Inhibition of transcription elongation by the VHL tumor suppressor protein

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

The von Hippel-Lindau tumor suppressor protein

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7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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7 January 2021

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

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7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

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7 January 2021

Induction of HIF-1alpha in response to hypoxia is instantaneous

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7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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7 January 2021

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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7 January 2021

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

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7 January 2021

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

1 reference

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7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

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7 January 2021

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

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7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Comparative sequence analysis of the VHL tumor suppressor gene

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

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7 January 2021

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

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7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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7 January 2021

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

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7 January 2021

Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

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7 January 2021

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

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7 January 2021

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

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7 January 2021

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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7 January 2021

Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy

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7 January 2021

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

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7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

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7 January 2021

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

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7 January 2021

On the Origin of Cancer Cells

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7 January 2021

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

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7 January 2021

Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia.

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7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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7 January 2021

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

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7 January 2021

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

Transcriptional response to hypoxia in human tumors

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7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

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7 January 2021

The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways

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7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900103-7

7 January 2021

10.1016/S1044-579X(02)00103-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference