(Q35055629)

6 August 2017

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title

Adaptors as central mediators of signal transduction in immune cells (English)

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6 August 2017

Martha S Jordan

1

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6 August 2017

Andrew L Singer

series ordinal

2

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6 August 2017

Gary A Koretzky

series ordinal

3

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

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6 August 2017

4

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6 August 2017

110-116

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6 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/ni0203-110

6 August 2017

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cites work

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Essential role of LAT in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Differential role of SLP-76 domains in T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Coupling of the TCR to integrin activation by Slap-130/Fyb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Adapters in lymphocyte signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Negative regulation of immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

X-linked lymphoproliferative disease: a progressive immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

BLNK: a central linker protein in B cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

An essential role for BLNK in human B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Regulation of ITAM signaling by specific sequences in Ig-beta B cell antigen receptor subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Scaffolds, adaptors and linkers of TCR signaling: theory and practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Signalling scaffolds and adaptors in T-cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The T-cell receptor signalosome: a dynamic structure with expanding complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

T cell receptor signaling precedes immunological synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Staging and resetting T cell activation in SMACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

LAB: a new membrane-associated adaptor molecule in B cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Costimulation: building an immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

Differential requirement for SLP-76 domains in T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

Requirement for the SLP-76 adaptor GADS in T cell development

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

Stimulation of the high-affinity IgE receptor results in the tyrosine phosphorylation of a 60 kD protein which is associated with the protein-tyrosine kinase, Csk

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0203-110

7 January 2021

Identifiers

DOI

10.1038/NI0203-110

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference