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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
author
Bart De Strooper
series ordinal
1
object named as
Bart De Strooper
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
language of work or name
English
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publication date
1 April 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
published in
Neuron
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stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
volume
38
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stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
page(s)
9-12
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stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
issue
1
1 reference
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Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
cites work
A cell biological perspective on Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
1 reference
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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
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7 January 2021
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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
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7 January 2021
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Mice lacking both presenilin genes exhibit early embryonic patterning defects
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
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APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of presenilin cofactors in the gamma-secretase complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0896-6273(03)00205-8
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
PubMed ID
12691659
1 reference
stated in
Europe PubMed Central
PubMed ID
12691659
retrieved
6 August 2017
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