(Q35106359)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice (English)

1 reference

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25 January 2020

0 references

1

1 reference

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25 January 2020

Peter A. Pechan

8

1 reference

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25 January 2020

William W Hauswirth

10

1 reference

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25 January 2020

author name string

Ji-Jing Pang

2

1 reference

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25 January 2020

Xiaoguang Cao

3

1 reference

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25 January 2020

Defen Shen

4

1 reference

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25 January 2020

Jun Zhang

5

1 reference

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25 January 2020

Abraham Scaria

6

1 reference

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25 January 2020

Samuel C Wadsworth

7

1 reference

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25 January 2020

Sanford L Boye

9

1 reference

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25 January 2020

Chi-Chao Chan

11

1 reference

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25 January 2020

publication date

12 March 2011

1 reference

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25 January 2020

published in

Neurobiology of Aging

1 reference

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25 January 2020

volume

33

1 reference

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25 January 2020

issue

2

1 reference

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25 January 2020

page(s)

433.e1-10

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Peroxisome Proliferator-Activated Receptor Expression in Murine Models and Humans with Age-related Macular Degeneration.

25 January 2020

cites work

1 reference

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Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.

9 July 2018

1 reference

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The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice

9 July 2018

1 reference

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Adeno-associated vector (type 8)-mediated expression of soluble Flt-1 efficiently inhibits neovascularization in a murine choroidal neovascularization model

9 July 2018

1 reference

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Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.

9 July 2018

1 reference

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Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD.

9 July 2018

1 reference

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Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways

9 July 2018

1 reference

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A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration

9 July 2018

1 reference

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A2E, a component of lipofuscin, is pro-angiogenic in vivo

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

rAAV.sFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-kappaB and MAPK activity

9 July 2018

1 reference

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VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

AAV-mediated gene therapy for retinal disorders: from mouse to man.

9 July 2018

1 reference

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A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Panretinal, high-resolution color photography of the mouse fundus

9 July 2018

1 reference

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9 July 2018

1 reference

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9 July 2018

1 reference

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Adeno-associated virus as a gene therapy vector: vector development, production and clinical applications.

9 July 2018

1 reference

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Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys

9 July 2018

1 reference

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Adeno-associated virus vectors in clinical trials

9 July 2018

1 reference

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RPE lipofuscin and its role in retinal pathobiology

9 July 2018

1 reference

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The neuroprotective function of vascular endothelial growth factor (VEGF).

9 July 2018

1 reference

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Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration

9 July 2018

1 reference

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Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

9 July 2018

1 reference

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Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization

9 July 2018

1 reference

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Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization

9 July 2018

1 reference

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Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

9 July 2018

1 reference

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Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase

9 July 2018

1 reference

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Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

9 July 2018

1 reference

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Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages

9 July 2018

1 reference

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The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

9 July 2018

1 reference

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Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136657

Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization.

27 September 2018

1 reference

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Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.

27 September 2018

1 reference

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Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis

27 September 2018

1 reference

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Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).

27 September 2018

1 reference

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10.1016/J.NEUROBIOLAGING.2011.01.009

27 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

21397984

1 reference