(Q35127441)

6 August 2017

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase (English)

1 reference

6 August 2017

Lin Wang

1

1 reference

6 August 2017

Nina M Goodey

series ordinal

2

1 reference

6 August 2017

Stephen J Benkovic

series ordinal

3

1 reference

6 August 2017

Amnon Kohen

series ordinal

4

1 reference

6 August 2017

language of work or name

English

0 references

publication date

10 October 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

1 reference

6 August 2017

103

1 reference

6 August 2017

15753-15758

1 reference

6 August 2017

43

1 reference

Electrostatic basis for enzyme catalysis

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Tunneling and dynamics in enzymatic hydride transfer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Relating protein motion to catalysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Hydrogen tunneling and protein motion in enzyme reactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Effects of a distal mutation on active site chemistry

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

How enzymes work: analysis by modern rate theory and computer simulations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Barrier passage and protein dynamics in enzymatically catalyzed reactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Network of coupled promoting motions in enzyme catalysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Hydrogen tunneling in biology

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Stretching exercises--flexibility in dihydrofolate reductase catalysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Insights into enzyme function from studies on mutants of dihydrofolate reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

13 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Microscale synthesis of 2-tritiated isopropanol and 4R-tritiated reduced nicotinamide adenine dinucleotide phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Synthesis and utility of 14C-labeled nicotinamide cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

A new conceptual framework for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Effect of mutation on enzyme motion in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Why bother about clumsiness? The implications of having developmental coordination disorder (DCD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Enzyme Catalysis: Beyond Classical Paradigms†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Freezing a single distal motion in dihydrofolate reductase.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Synthesis of R and S tritiated reduced beta-nicotinamide adenine dinucleotide 2' phosphate

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1635075

Crystalline Dihydropteroylglutamic Acid

27 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606976103

Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization

21 January 2018

1 reference

12 December 2020

A method of preparation and purification of (4R)-deuterated-reduced nicotinamide adenine dinucleotide phosphate

1 reference

12 December 2020

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

1 reference

12 December 2020

Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase

1 reference

12 December 2020

Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0606976103

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference