(Q35148800)

6 August 2017

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title

Metabolic and molecular basis of insulin resistance (English)

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6 August 2017

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2

Ralph A Defronzo

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6 August 2017

Mandeep Bajaj

1

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6 August 2017

1 May 2003

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Journal of Nuclear Cardiology

6 August 2017

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6 August 2017

10

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6 August 2017

311-323

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6 August 2017

3

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https://scigraph.springernature.com/pub.10.1016/s1071-3581(03)00520-8

6 August 2017

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cites work

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12 December 2020

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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12 December 2020

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

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12 December 2020

Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

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12 December 2020

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss

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12 December 2020

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

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12 December 2020

The fourth musketeer--from Alexandre Dumas to Claude Bernard

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12 December 2020

Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis

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12 December 2020

Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.

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12 December 2020

Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans

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12 December 2020

Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism

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12 December 2020

Activation of phosphatidylinositol 3-kinase by insulin

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12 December 2020

The structure and regulation of protein phosphatases

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12 December 2020

In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus

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12 December 2020

Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus

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12 December 2020

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance

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12 December 2020

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

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12 December 2020

Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM.

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12 December 2020

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

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12 December 2020

Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.

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12 December 2020

Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects

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12 December 2020

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus

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12 December 2020

Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects

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12 December 2020

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus

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12 December 2020

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes

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12 December 2020

Glucose ingestion causes GLUT4 translocation in human skeletal muscle.

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12 December 2020

Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomography

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12 December 2020

Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM

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12 December 2020

Expression and function of IRS-1 in insulin signal transmission.

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12 December 2020

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

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12 December 2020

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

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12 December 2020

Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo

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12 December 2020

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

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12 December 2020

The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization

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12 December 2020

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

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12 December 2020

Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus

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12 December 2020

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

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12 December 2020

Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

1 reference

12 December 2020

Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects

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12 December 2020

Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.

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12 December 2020

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation

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12 December 2020

Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.

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12 December 2020

Renal gluconeogenesis: its importance in human glucose homeostasis

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12 December 2020

Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance.

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12 December 2020

Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus.

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12 December 2020

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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12 December 2020

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

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12 December 2020

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

1 reference

12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

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12 December 2020

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

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12 December 2020

Intracellular defects in glucose metabolism in obese patients with NIDDM.

1 reference

12 December 2020

Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance

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12 December 2020

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution

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12 December 2020

Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM

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12 December 2020

Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus

1 reference

12 December 2020

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms

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12 December 2020

Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals

1 reference

12 December 2020

Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM.

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action.

1 reference

12 December 2020

Splanchnic and peripheral disposal of oral glucose in man

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12 December 2020

Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.

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12 December 2020

Kinetics of human connecting peptide in normal and diabetic subjects

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12 December 2020

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients

1 reference

12 December 2020

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

1 reference

12 December 2020

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

1 reference

12 December 2020

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

12 December 2020

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1

1 reference

12 December 2020

Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy.

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12 December 2020

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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12 December 2020

Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein?

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12 December 2020

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.

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12 December 2020

A comparison of brain glucose metabolism in diabetes as measured by positron emission tomography or by arteriovenous techniques.

1 reference

12 December 2020

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

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12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

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12 December 2020

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

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12 December 2020

Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

1 reference

12 December 2020

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

Diabetes trends in the U.S.: 1990-1998.

1 reference

12 December 2020

Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake

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12 December 2020

Lactate release from the subcutaneous tissue in lean and obese men.

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12 December 2020

Fuel selection in human skeletal muscle in insulin resistance: a reexamination

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12 December 2020

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

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12 December 2020

Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion

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12 December 2020

NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

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12 December 2020

Sequential changes in serum insulin concentration during development of non-insulin-dependent diabetes.

1 reference

12 December 2020

Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle

1 reference

12 December 2020

10.1016/S1071-3581(03)00520-8

Identifiers

DOI

1 reference

PubMed ID

12794631

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12794631