(Q35149292)

6 August 2017

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title

Reversal of tumor-induced immunosuppression by TGF-beta inhibitors (English)

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6 August 2017

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Slawomir Wojtowicz-Praga

series ordinal

1

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6 August 2017

1 February 2003

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Investigational New Drugs

6 August 2017

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6 August 2017

21

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6 August 2017

21-32

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6 August 2017

1

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https://scigraph.springernature.com/pub.10.1023/a:1022951824806

6 August 2017

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cites work

Serum transforming growth factor-beta 1 is related to the degree of immunoparesis in patients with multiple myeloma

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12 December 2020

Transforming growth factor beta 1-hyaluronic acid interaction

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12 December 2020

Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line

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12 December 2020

Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy.

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12 December 2020

Altered expression of transforming growth factor-beta ligands and receptors in primary and recurrent ovarian carcinoma

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12 December 2020

Expression of transforming growth factor-beta 1 in prostate cancer.

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12 December 2020

Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo

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12 December 2020

TGF-beta-based immunotherapy for cancer: breaching the tumor firewall

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12 December 2020

Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta

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12 December 2020

Reversal of tumor-induced immunosuppression: a new approach to cancer therapy

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12 December 2020

Transforming growth factor beta signaling through Smad1 in human breast cancer cells

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12 December 2020

Multiple forms of TGF-beta 1 in breast tissues: a biologically active form of the small latent complex of TGF-beta 1.

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12 December 2020

Transforming growth factor beta1, urokinase-type plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa

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12 December 2020

The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy.

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12 December 2020

Tranilast Kissei Pharmaceutical

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12 December 2020

Autocrine stimulatory mechanism by transforming growth factor beta in human hepatocellular carcinoma

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12 December 2020

Transforming growth factor-beta in in vivo resistance

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12 December 2020

Smad6 inhibits signalling by the TGF-beta superfamily.

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12 December 2020

Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth factor-beta in the presence of interleukin-2.

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12 December 2020

Immunological measurement of transforming growth factor-beta 1 (TGF-beta1) in blood; assay development and comparison

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12 December 2020

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

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12 December 2020

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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12 December 2020

Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice

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12 December 2020

Inhibition of tumor necrosis factor-alpha and -beta secretion by lymphokine activated killer cells by transforming growth factor-beta.

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12 December 2020

The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells

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12 December 2020

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

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12 December 2020

Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation

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12 December 2020

Smads are the central component in transforming growth factor-beta signaling.

1 reference

12 December 2020

Combination of transforming growth factor beta antisense and interleukin-2 gene therapy in the murine ovarian teratoma model

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12 December 2020

Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines

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12 December 2020

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer

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12 December 2020

Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma

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12 December 2020

Regulation of adhesion and adhesion molecules in endothelium by transforming growth factor-beta

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12 December 2020

Regulation of osteogenesis by fetuin.

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12 December 2020

Constitutive secretion of bioactive transforming growth factor beta 1 by small cell lung cancer cell lines

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12 December 2020

Association of transforming growth factor-beta 1 with prostate cancer: an immunohistochemical study

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12 December 2020

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

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12 December 2020

Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha

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12 December 2020

The complete cDNA and amino acid sequence of bovine fetuin. Its homology with alpha 2HS glycoprotein and relation to other members of the cystatin superfamily.

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12 December 2020

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1 reference

12 December 2020

Transforming growth factor-beta signaling in epithelial cells

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12 December 2020

Tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid) down-regulates the growth of scirrhous gastric cancer.

1 reference

12 December 2020

Transforming growth factor beta and cancer

1 reference

12 December 2020

Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

1 reference

12 December 2020

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival

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12 December 2020

Transforming growth factor beta from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes

1 reference

12 December 2020

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

12 December 2020

Expression of transforming growth factor-beta1 and transforming growth factor-beta Type-II receptor mRNA in papillary thyroid carcinoma

1 reference

12 December 2020

Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca(2+)-permeable channel

1 reference

12 December 2020

SMADs: mediators and regulators of TGF-beta signaling

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12 December 2020

Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15.

1 reference

12 December 2020

Transforming growth factor-beta: latent forms, binding proteins and receptors

1 reference

12 December 2020

The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

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12 December 2020

Cytokine profile of cervical cancer cells.

1 reference

12 December 2020

Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.

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12 December 2020

Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation

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12 December 2020

Transforming growth factor-beta and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo

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12 December 2020

Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity

1 reference

12 December 2020

Expression of transforming growth factor-beta 1 in human bladder cancer

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12 December 2020

Secretion of transforming growth factor-beta 1 and -beta 2 by malignant glioma cells

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12 December 2020

Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in rats.

1 reference

12 December 2020

TGF-beta receptors: structure and function

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12 December 2020

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

1 reference

12 December 2020

N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-beta relesase and reduces migration and invasiveness of human malignant glioma cells

1 reference

12 December 2020

Activation of latent transforming growth factor beta

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12 December 2020

Regulation of antibody production and class switching by TGF-beta.

1 reference

12 December 2020

Anti-(transforming growth factor beta) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice

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12 December 2020

Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation

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12 December 2020

Role of transforming growth factor-beta1 in the suppressed allostimulatory function of AIDS patients

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12 December 2020

Effect of the expression of transforming growth factor-beta 2 in primary human glioblastomas on immunosuppression and loss of immune surveillance

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12 December 2020

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system

1 reference

12 December 2020

Effects of anti-transforming growth factor-beta antibody and interleukin-2 in tumor-bearing mice.

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12 December 2020

Transforming growth factor-beta in breast cancer: a working hypothesis

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12 December 2020

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

1 reference

12 December 2020

Inhibition of interferon-gamma and interleukin-2 production from lymphocytes stimulated with food antigens by an anti-allergic drug, Tranilast, in patients with food-sensitive atopic dermatitis

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12 December 2020

TGF-beta signaling in tumor suppression and cancer progression

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12 December 2020

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

1 reference

12 December 2020

Negative regulation of transforming growth factor-beta by the proteoglycan decorin

1 reference

12 December 2020

Transforming growth factor beta 1 is significantly elevated in plasma of patients suffering from renal cell carcinoma

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12 December 2020

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

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12 December 2020

In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin

1 reference

12 December 2020

Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

1 reference

12 December 2020

Expression of transforming growth factor-beta 2 in malignant melanoma correlates with the depth of tumor invasion. Implications for tumor progression

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12 December 2020

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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12 December 2020

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1 reference

12 December 2020

Generation of lymphokine-activated killer activity in T cells. Possible regulatory circuits

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12 December 2020

Altered transforming growth factor signaling in epithelial cells when ras activation is blocked

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12 December 2020

Cyclosporine induces cancer progression by a cell-autonomous mechanism.

1 reference

12 December 2020

Role of transforming growth factor beta in cancer

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12 December 2020

Increase of plasma transforming growth factor beta (TGF beta) during immunotherapy with IL-2.

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12 December 2020

Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries.

1 reference

12 December 2020

Analysis of the TGF beta functional pathway in epithelial ovarian carcinoma

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12 December 2020

Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells

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12 December 2020

Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer

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12 December 2020

Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture

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12 December 2020

Transforming growth factor beta and fibroblast growth factor as promoters of tumor progression to malignancy

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12 December 2020

Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2

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12 December 2020

TGF-beta receptors and signalling mechanisms

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12 December 2020

Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures

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12 December 2020

Antisense oligonucleotides specific for transforming growth factor beta2 inhibit the growth of malignant mesothelioma both in vitro and in vivo

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12 December 2020

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1 reference

12 December 2020

Immunohistochemical localization of transforming growth factor-beta 1 in Kaposi's sarcoma

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12 December 2020

Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist

1 reference

12 December 2020

Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

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12 December 2020

Pleiotropic effects of transforming growth factor-beta on cells of the immune system

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12 December 2020

Transforming growth factor-beta: expression in normal and pathological conditions

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12 December 2020

TGF-beta, radiation-induced pulmonary injury and lung cancer

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12 December 2020

Transforming growth factor beta and the cell surface in tumor progression

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12 December 2020

Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells

1 reference

12 December 2020

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

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12 December 2020

Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes

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12 December 2020

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy

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12 December 2020

TGF-beta: structure, function, and formation

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12 December 2020

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells

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12 December 2020

Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo

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12 December 2020

Origin of plasma alpha2HS-glycoprotein and its accumulation in bone

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12 December 2020

Immunotherapy with low-dose interleukin-2 and anti-transforming growth factor-beta antibody in a murine tumor model

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12 December 2020

Identifiers

DOI

10.1023/A:1022951824806

1 reference

PubMed ID

12795527

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12795527