(Q35178872)

7 August 2017

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title

SH2 and PTB domains in tyrosine kinase signaling (English)

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7 August 2017

2

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7 August 2017

1

Joseph Schlessinger

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7 August 2017

15 July 2003

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Science's STKE : signal transduction knowledge environment

7 August 2017

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7 August 2017

2003

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7 August 2017

RE12

1 reference

7 August 2017

191

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SH2 domains, interaction modules and cellular wiring

7 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Genome-wide analysis of signaling domain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

PDGF induction of tyrosine phosphorylation of GTPase activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Binding of GAP to activated PDGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Src homology region 2 domains direct protein-protein interactions in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Modular peptide recognition domains in eukaryotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

SH2 and PTB domain interactions in tyrosine kinase signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Cell signaling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Signaling--2000 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Activation of Ras and other signaling pathways by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Adaptors as central mediators of signal transduction in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Essential role of LAT in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Autoregulatory mechanisms in protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Stats: transcriptional control and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

SOCS proteins: negative regulators of cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Negative receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

A phosphotyrosine interaction domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

SMART, a simple modular architecture research tool: identification of signaling domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The function of PTB domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The PH superfold: a structural scaffold for multiple functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Peptide-surface association: the case of PDZ and PTB domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

PTB or not PTB -- that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

PTB domain of insulin receptor substrate-1 binds inositol compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The phosphotyrosine binding-like domain of talin activates integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural determinants of integrin recognition by talin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.191.RE12

10.1126/STKE.2003.191.RE12

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12865499