(Q35194419)

7 August 2017

1 reference

title

The role of investigative molecular toxicology in early stage drug development (English)

1 reference

7 August 2017

Cindy J Gross

1

1 reference

PubMed ID

12904115

7 August 2017

Jeffrey A Kramer

series ordinal

2

1 reference

PubMed ID

12904115

7 August 2017

language of work or name

English

0 references

publication date

1 March 2003

1 reference

Expert Opinion on Drug Safety

7 August 2017

1 reference

7 August 2017

2

1 reference

7 August 2017

147-159

1 reference

7 August 2017

2

1 reference

A guide to drug discovery: Target selection in drug discovery

7 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

The assessment of potential for QT interval prolongation with new pharmaceuticals: impact on drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Returns to R&D on new drug introductions in the 1980s

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Toxicogenomics: an opportunity to optimise drug development and safety evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Clinical proteomics: translating benchside promise into bedside reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Metabonomics: a platform for studying drug toxicity and gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Analysis of cytochrome P450 and phase II conjugating enzyme expression in adult male rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

The use of genomics technology to investigate gene expression changes in cultured human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Temporal gene expression analysis of monolayer cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Mechanisms and pathogenesis of thyroid cancer in animals and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

The rat as model for the study of drug effects on thyroid function: Consideration of methodological problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Peroxisome proliferator-activated receptors: structures and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Mechanisms of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Cytochrome c: can't live with it--can't live without it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Autophagic cell death and its execution by lysosomal cathepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Hepatotoxicity due to mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Antioxidants and oxidants regulated signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Cationic amphiphilic drug-induced phospholipidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Antidepressant-induced lipidosis with special reference to tricyclic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Drug-induced allergic hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2.2.147

21 January 2018

Identifiers

DOI

10.1517/14740338.2.2.147

1 reference

7 August 2017

1 reference

PubMed ID

12904115