(Q35196302)

7 August 2017

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title

Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals (English)

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amyotrophic lateral sclerosis

7 August 2017

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author name string

Maria Teresa Carrí

1

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7 August 2017

Alberto Ferri

2

1 reference

7 August 2017

Mauro Cozzolino

3

1 reference

7 August 2017

Lilia Calabrese

4

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7 August 2017

Giuseppe Rotilio

5

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7 August 2017

language of work or name

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1 August 2003

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7 August 2017

Brain Research Bulletin

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7 August 2017

61

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7 August 2017

365-374

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7 August 2017

4

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Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondria and the pathogenesis of ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Increased oxidative damage to DNA in ALS patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

SOD1 aggregates in ALS: cause, correlate or consequence?

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Normal prion protein has an activity like that of superoxide dismutase.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Impaired copper binding by the H46R mutant of human Cu,Zn superoxide dismutase, involved in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial DNA deletion mutation levels are elevated in ALS brains

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial reactive oxygen species in cell death signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Aberrant copper chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Reactive oxygen species and the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Regulation of the 75-kDa subunit of mitochondrial complex I by iron

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Cellular distribution of superoxide dismutases in the rat CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

The role of O2.- in the production of HO.: in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Amyotrophic lateral sclerosis: copper/zinc superoxide dismutase (SOD1) gene mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Identification of an apo-superoxide dismutase (Cu,Zn) pool in human lymphoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Molecular mechanisms of copper uptake and distribution

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Pathways to motor neuron degeneration in transgenic mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Oxidative damage to protein in sporadic motor neuron disease spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Yeast lacking superoxide dismutase(s) show elevated levels of "free iron" as measured by whole cell electron paramagnetic resonance

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Copper-dependent metabolism of Cu,Zn-superoxide dismutase in human K562 cells. Lack of specific transcriptional activation and accumulation of a partially inactivated enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondria in sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Copper, ceruloplasmin and superoxide dismutase (SOD) in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Do oxidatively modified proteins cause ALS?

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900179-5

7 January 2021

10.1016/S0361-9230(03)00179-5

Identifiers

DOI

1 reference

7 August 2017

1 reference