(Q35351671)

7 August 2017

Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein (English)

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7 August 2017

2

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7 August 2017

3

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7 August 2017

J H Laity

1

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PubMed ID

11050227

7 August 2017

language of work or name

English

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publication date

1 October 2000

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

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7 August 2017

97

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7 August 2017

11932-11935

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7 August 2017

22

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Alternative splicing of Wilms' tumor suppressor protein modulates DNA binding activity through isoform-specific DNA-induced conformational changes

7 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Donor splice-site mutations in WT1 are responsible for Frasier syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

RNA binding by the Wilms tumor suppressor zinc finger proteins.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Does the Wilms' tumour suppressor gene, WT1, play roles in both splicing and transcription?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

The WT1 Wilms' tumor suppressor gene: how much do we really know?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Spectral density function mapping using 15N relaxation data exclusively

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

WT-1 is required for early kidney development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

The role of WT1 in Wilms tumorigenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

The genetics of Wilms' tumor--a case of disrupted development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

A specific transcription factor that can bind either the 5S RNA gene or 5S RNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Alternative splicing and genomic structure of the Wilms tumor gene WT1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Molecular basis for specific recognition of both RNA and DNA by a zinc finger protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

Long-range motional restrictions in a multidomain zinc-finger protein from anisotropic tumbling.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17272

DNA-induced α-helix capping in conserved linker sequences is a determinant of binding affinity in Cys2-His2 zinc fingers

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.22.11932

Temperature dependence of intramolecular dynamics of the basic leucine zipper of GCN4: implications for the entropy of association with DNA

21 January 2018

1 reference

12 December 2020

Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation

1 reference

12 December 2020

Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript

1 reference

12 December 2020

Comparison of the DNA binding characteristics of the related zinc finger proteins WT1 and EGR1

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.97.22.11932

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference

PubMed ID

11050227