(Q35610289)

9 August 2017

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title

Proteinase-activated receptors in the nervous system (English)

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9 August 2017

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Nathalie Vergnolle

2

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author name string

Farshid Noorbakhsh

series ordinal

1

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9 August 2017

Morley D Hollenberg

series ordinal

3

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9 August 2017

Christopher Power

series ordinal

4

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9 August 2017

language of work or name

English

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publication date

1 December 2003

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Nature Reviews Neuroscience

9 August 2017

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9 August 2017

4

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9 August 2017

981-990

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9 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrn1255

9 August 2017

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cites work

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A dual thrombin receptor system for platelet activation

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PAR3 is a cofactor for PAR4 activation by thrombin

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

31 March 2020

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR-2

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Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

31 March 2020

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Thrombin signalling and protease-activated receptors

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Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells.

31 March 2020

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Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

31 March 2020

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Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

31 March 2020

1 reference

Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons.

31 March 2020

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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

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Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.

31 March 2020

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Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons

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Prothrombin mRNA is expressed by cells of the nervous system.

31 March 2020

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Production of thrombin and antithrombin III by brain and astroglial cell cultures.

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Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

31 March 2020

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Expression of factor X in both the rat brain and cells of the central nervous system

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Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves

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Mast cells: the immune gate to the brain

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Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2

31 March 2020

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Cloning of the cDNA encoding human brain trypsinogen and characterization of its product

31 March 2020

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Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

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Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture.

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A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responses

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Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

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The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes

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Thrombin is a regulator of astrocytic endothelin-1.

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Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes

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Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture

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The metabotropic glutamate receptor mGluR5 induces calcium oscillations in cultured astrocytes via protein kinase C phosphorylation

31 March 2020

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Thrombin modulates and reverses neuroblastoma neurite outgrowth

31 March 2020

1 reference

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

31 March 2020

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Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons.

31 March 2020

1 reference

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

31 March 2020

1 reference

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

31 March 2020

1 reference

Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction

31 March 2020

1 reference

Proteolytic activity, synapse elimination, and the Hebb synapse

31 March 2020

1 reference

Potentiation of NMDA receptor function by the serine protease thrombin

31 March 2020

1 reference

Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

31 March 2020

1 reference

Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons

31 March 2020

1 reference

Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats

31 March 2020

1 reference

Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine

31 March 2020

1 reference

Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli

31 March 2020

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Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

31 March 2020

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The proteinase-activated receptor 2 is involved in nociception.

31 March 2020

1 reference

Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.

31 March 2020

1 reference

Injury-induced gelatinase and thrombin-like activities in regenerating and nonregenerating nervous systems

31 March 2020

1 reference

Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

31 March 2020

1 reference

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

31 March 2020

1 reference

Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers

31 March 2020

1 reference

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

31 March 2020

1 reference

Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system

31 March 2020

1 reference

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

31 March 2020

1 reference

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

31 March 2020

1 reference

Apoptosis in neurodegenerative disorders

31 March 2020

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Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis

31 March 2020

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Thrombin-induced activation of cultured rodent microglia

31 March 2020

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Participation of protease-activated receptor-1 in thrombin-induced microglial activation

31 March 2020

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Signaling pathways involved in thrombin-induced cell protection

31 March 2020

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

31 March 2020

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Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning.

31 March 2020

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Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance

31 March 2020

1 reference

Thrombin may contribute to the pathophysiology of central nervous system injury.

31 March 2020

1 reference

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

31 March 2020

1 reference

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

31 March 2020

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Neuroimmune and neurovirological aspects of human immunodeficiency virus infection

31 March 2020

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31 March 2020

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The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?

31 March 2020

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31 March 2020

1 reference

Conformational rearrangements required of the V3 loop of HIV-1 gp120 for proteolytic cleavage and infection

31 March 2020

1 reference

Enhanced proteolytic processing of the human immunodeficiency virus type 1 envelope protein in murine Ltk(-) cells

31 March 2020

1 reference

Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus

31 March 2020

1 reference

T-cell membrane-associated serine protease, tryptase TL2, binds human immunodeficiency virus type 1 gp120 and cleaves the third-variable-domain loop of gp120. Neutralizing antibodies of human immunodeficiency virus type 1 inhibit cleavage of gp120.

31 March 2020

1 reference

Interaction between a membrane-associated serine proteinase of U-937 monocytes and peptides from the V3 loop of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein

31 March 2020

1 reference

Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G

31 March 2020

1 reference

Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and V3 loop-derived peptides from several strains of HIV-1.

31 March 2020

1 reference

Characterization of a Neutralizing Monoclonal Antibody to the External Glycoprotein of HIV-1

31 March 2020

1 reference

Role of HIV-1 envelope V3 loop cleavage in cell tropism

31 March 2020

1 reference

The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

31 March 2020

1 reference

Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases

31 March 2020

1 reference

Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases

31 March 2020

1 reference

Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains.

31 March 2020

1 reference

The mast cells of the multiple sclerosis brain.

31 March 2020

1 reference

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

31 March 2020

1 reference

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

31 March 2020

1 reference

Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

31 March 2020

1 reference

Proteinase-activated receptors (PARs): activation of PAR1 and PAR2 by a proteolytic fragment of the neuronal growth associated protein B-50/GAP-43

31 March 2020

1 reference

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

31 March 2020

1 reference

Thrombin Induces Proteinase-activated Receptor-1 Gene Expression in Endothelial Cells via Activation of Gi-linked Ras/Mitogen-activated Protein Kinase Pathway

31 March 2020

1 reference

Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN1255

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Dimensions Publication ID

9 August 2017

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1 reference