(Q35621375)

9 August 2017

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title

The IKK NF-kappa B system: a treasure trove for drug development (English)

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9 August 2017

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1

Michael Karin

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9 August 2017

Yumi Yamamoto

2

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PubMed ID

14708018

9 August 2017

Q May Wang

series ordinal

3

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PubMed ID

14708018

9 August 2017

language of work or name

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1 January 2004

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Nature Reviews Drug Discovery

9 August 2017

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9 August 2017

3

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9 August 2017

17-26

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9 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrd1279

9 August 2017

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cites work

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

31 March 2020

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RelB cellular regulation and transcriptional activity are regulated by p100.

31 March 2020

1 reference

Missing pieces in the NF-kappaB puzzle

31 March 2020

1 reference

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

31 March 2020

1 reference

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

31 March 2020

1 reference

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

31 March 2020

1 reference

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

31 March 2020

1 reference

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

31 March 2020

1 reference

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

31 March 2020

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

31 March 2020

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IKKalpha controls formation of the epidermis independently of NF-kappaB.

31 March 2020

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

31 March 2020

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

31 March 2020

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31 March 2020

A regulator branches out

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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NF-kappaB at the crossroads of life and death

31 March 2020

1 reference

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

31 March 2020

1 reference

Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease

31 March 2020

1 reference

Rel/NF-kappa B and I kappa B factors in oncogenesis

31 March 2020

1 reference

NF-kappa B: arresting a major culprit in cancer

31 March 2020

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Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

31 March 2020

1 reference

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

31 March 2020

1 reference

Clinical update: proteasome inhibitors in solid tumors

31 March 2020

1 reference

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

31 March 2020

1 reference

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

31 March 2020

1 reference

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

31 March 2020

1 reference

Stabilization of beta-catenin by genetic defects in melanoma cell lines

31 March 2020

1 reference

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

31 March 2020

1 reference

Inhibition of NF-kappa B by sodium salicylate and aspirin

31 March 2020

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

31 March 2020

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Sulindac inhibits activation of the NF-kappaB pathway

31 March 2020

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Combination of tumor necrosis factor-alpha with sulindac augments its apoptotic potential and suppresses tumor growth of human carcinoma cells in nude mice

31 March 2020

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

31 March 2020

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Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.

31 March 2020

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Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

31 March 2020

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Thalidomide analogs as emerging anti-cancer drugs

31 March 2020

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Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

31 March 2020

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Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester

31 March 2020

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Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

31 March 2020

1 reference

Inducible cyclooxygenase may have anti-inflammatory properties

31 March 2020

1 reference

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

31 March 2020

1 reference

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

31 March 2020

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15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

31 March 2020

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Possible new role for NF-kappaB in the resolution of inflammation.

31 March 2020

1 reference

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

31 March 2020

1 reference

Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation

31 March 2020

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Protein oxidation in aging, disease, and oxidative stress

31 March 2020

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Evidence that reactive oxygen species do not mediate NF-kappaB activation

31 March 2020

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NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

31 March 2020

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

31 March 2020

1 reference

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: an inhibitor of AP-1 and NF-kappaB mediated gene expression

31 March 2020

1 reference

Novel IKK inhibitors: beta-carbolines

31 March 2020

1 reference

NF-kappa B as a therapeutic target in multiple myeloma

31 March 2020

1 reference

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

31 March 2020

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A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

31 March 2020

1 reference

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

31 March 2020

1 reference

Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.

31 March 2020

1 reference

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis

31 March 2020

1 reference

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

31 March 2020

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1279

1 reference

9 August 2017

1 reference

PubMed ID

14708018