(Q35635353)

9 August 2017

1 reference

title

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis (English)

1 reference

9 August 2017

Steelman LS

1

1 reference

9 August 2017

Pohnert SC

2

1 reference

9 August 2017

Shelton JG

3

1 reference

9 August 2017

Franklin RA

4

1 reference

9 August 2017

Bertrand FE

5

1 reference

9 August 2017

McCubrey JA

6

1 reference

9 August 2017

language of work or name

1 reference

1 February 2004

1 reference

9 August 2017

1 reference

9 August 2017

18

1 reference

9 August 2017

189-218

1 reference

9 August 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403241

9 August 2017

0 references

cites work

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Serine/threonine phosphorylation in cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Kinases: positive and negative regulators of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning and nucleotide sequence of the murine interleukin-3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Sequential mutations in the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated beta C subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Signaling through the JAK/STAT pathway, recent advances and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

SOCS proteins: negative regulators of cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Jak2 is essential for signaling through a variety of cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Evolutionary analysis for functional divergence of Jak protein kinase domains and tissue-specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Jak2-Stat5 interactions analyzed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Genomic sequence, organization, and chromosomal localization of human JAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The role of Jak3 in lymphoid development, activation, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Role of Jak kinases and STATs in cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Jak-STAT signaling induced by the v-abl oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

JAK-STAT signaling activated by Abl oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning and characterization of novel CIS family genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Twenty proteins containing a C-terminal SOCS box form five structural classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Stat proteins and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

MEN2A-RET-induced cellular transformation by activation of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

STAT3 is constitutively activated in Hodgkin cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Interleukin-11 receptor expression in primary ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Constitutive activation of STAT5 by a point mutation in the SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Ki-ras oncogene mutations in chronic pancreatitis: which discriminating ability for malignant potential?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Endothelial apoptosis in Braf-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Isoform-specific localization of A-RAF in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Retroviral gene transfer of dominant negative raf-1 mutants suppresses ha-ras-induced transformation and delays tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation of c-Raf-1 by protein kinase A interferes with activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Untying the regulation of the Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Biochemical and biological analysis of Mek1 phosphorylation site mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Selective requirement for MAP kinase activation in thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

RAS signalling is abnormal in a c-raf1 MEK1 double mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Clinical development of farnesyltransferase inhibitors in leukemias and myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Chromosome and molecular abnormalities in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mechanisms of aflatoxin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Current status of clinical trials of farnesyltransferase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Developmentally-regulated expression of murine K-ras isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cancer genome targets: RAF-ing up tumor cells to overcome oncogene addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

High frequency of BRAF mutations in nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A genome-based strategy uncovers frequent BRAF mutations in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

K-ras p21 expression and activity in lung and lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Paradoxical activation of Raf by a novel Raf inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Discovery of a novel Raf kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

BAY 43-9006: preclinical data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

BAY 43-9006: early clinical data in patients with advanced solid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A novel cAMP-stimulated pathway in protein phosphatase 2A activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Protein kinase C inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Protein kinase C inhibitors as novel anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Protein kinase A as target for novel integrated strategies of cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Adenylyl cyclase: a new target for heart failure therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Tyrosine kinase inhibitors in the treatment of chronic myeloid leukaemia: so far so good?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

An essential role for Src kinase in ErbB receptor signaling through the MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Signalling via phosphoinositide 3OH kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Pathways for phosphoinositide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of phosphatidylinositol-3' kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

p110δ, a novel phosphoinositide 3-kinase in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structural and functional diversity of phosphoinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structural framework for the protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Inositide signalling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Receptor protein-tyrosine kinases and their signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Structure and function of phosphoinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Thymic lymphoma induction by the AKT8 murine retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The AKT1 proto-oncogene maps to human chromosome 14, band q32.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Pleckstrin domain homology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A putative modular domain present in diverse signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Akt participation in the Wnt signaling pathway through Dishevelled

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Neosis and its potential role in cancer development and chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

A novel germline mutation of PTEN associated with brain tumours of multiple lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

STAT signaling in the pathogenesis and treatment of leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Critical role for Gab2 in transformation by BCR/ABL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

ABL-kinase domain point mutation as a cause of imatinib (STI571) resistance in CML patient who progress to myeloid blast crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Cytogenetic and molecular mechanisms of resistance to imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Imatinib mesylate in combination with other chemotherapeutic drugs: in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Targeting oncogene dependence and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Interleukin-3 receptor in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Pharmacological inhibitors of MAPK pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Defective lymphoid development in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Cytogenetic and molecular heterogeneity of 7q36/12p13 rearrangements in childhood AML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

The role of Raf kinases in development and growth of tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Involvement of B-Raf in Ras-induced Raf-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Complex karyotype and N-RAS point mutation in a case of acute megakaryoblastic leukemia (M7) following a myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

BRAF Mutation in Papillary Thyroid Carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Ki-ras and the characteristics of mouse lung tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Apoptosis regulating proteins as targets of therapy for haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

T cell activation via the disialoganglioside GD3: analysis of signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Differentiation and malignant transformation: two roads diverged in a wood

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403241

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403241

1 reference

Dimensions Publication ID

9 August 2017

0 references

1 reference