(Q35681638)

9 August 2017

Molecular basis for Rho GTPase signaling specificity (English)

1 reference

9 August 2017

Antoine E Karnoub

1

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9 August 2017

Marc Symons

series ordinal

2

1 reference

9 August 2017

Sharon L Campbell

series ordinal

3

1 reference

9 August 2017

Channing J Der

series ordinal

4

1 reference

9 August 2017

language of work or name

English

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publication date

1 March 2004

1 reference

Breast Cancer Research and Treatment

9 August 2017

1 reference

9 August 2017

84

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9 August 2017

61-71

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9 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1023/b:brea.0000018427.84929.5c

9 August 2017

0 references

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Lck regulates Vav activation of members of the Rho family of GTPases

21 January 2018

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

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Structure of the TPR domain of p67phox in complex with Rac.GTP

21 January 2018

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Suppression of Ras-induced apoptosis by the Rac GTPase

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

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Targeting RAS signalling pathways in cancer therapy

21 January 2018

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7 January 2021

RHO-GTPases and cancer

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7 January 2021

The role of Rho GTPases in disease development

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7 January 2021

Rho GTPases are over-expressed in human tumors.

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7 January 2021

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

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7 January 2021

RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

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7 January 2021

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

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7 January 2021

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

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7 January 2021

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

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7 January 2021

DBC2, a candidate for a tumor suppressor gene involved in breast cancer

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https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

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https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rho GTPases in cell biology

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7 January 2021

Rho GTPases and signaling networks

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7 January 2021

Effectors for the Rho GTPases

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7 January 2021

Rho GTPases and the actin cytoskeleton

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7 January 2021

Rho GTPases. Integrating integrin signaling

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7 January 2021

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis

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7 January 2021

Ras signalling. Caught in the act of the switch-on.

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https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Dbl family guanine nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Isolation of a new human oncogene from a diffuse B-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rho GTPase-activating proteins in cell regulation

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https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Proteins regulating Ras and its relatives

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7 January 2021

GAPs for rho-related GTPases

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7 January 2021

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rho family GTPases: more than simple switches

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Pleckstrin homology domains and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A role for Rac in Tiam1-induced membrane ruffling and invasion

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Vav2 is an activator of Cdc42, Rac1, and RhoA

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structure and mutagenesis of the Dbl homology domain

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Determination of interaction sites on the small G protein RhoA for phospholipase D

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structure of Cdc42 bound to the GTPase binding domain of PAK

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

The ras protein family: evolutionary tree and role of conserved amino acids

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Specificity of Rho insert-mediated activation of phospholipase D1.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Transformation activity of Cdc42 requires a region unique to Rho-related proteins

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

The insert region of Rac1 is essential for membrane ruffling but not cellular transformation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

A Rac1 effector site controlling mitogenesis through superoxide production.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Structural determinants for the biological activity of Vav proteins.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

Localized Rac activation dynamics visualized in living cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018427.84929.5C

7 January 2021

10.1023/B:BREA.0000018427.84929.5C

Identifiers

DOI

1 reference

Dimensions Publication ID

9 August 2017

0 references

1 reference