(Q35705859)

9 August 2017

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing (English)

1 reference

9 August 2017

1 reference

24

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9 August 2017

15

Donna Muzny

0 references

Susan Woods

Susan L Woods

2

0 references

Vanessa F Bonazzi

Vanessa F Bonazzi

4

0 references

Sonika Tyagi

Sonika Tyagi

14

0 references

Jeffrey P MacKeigan

Jeffrey P MacKeigan

25

0 references

Mitchell S. Stark

Mitchell S Stark

1

0 references

Lauren Aoude

Lauren G Aoude

6

0 references

Christopher W. Schmidt

Christopher W Schmidt

23

0 references

Nicholas Hayward

Nicholas K Hayward

30

0 references

Jeffrey Trent

29

Jeffrey Trent

1 reference

9 August 2017

Michael G Gartside

3

1 reference

9 August 2017

Ken Dutton-Regester

5

1 reference

9 August 2017

Donald Chow

7

1 reference

9 August 2017

Chris Sereduk

8

1 reference

9 August 2017

Natalie M Niemi

9

1 reference

9 August 2017

Nanyun Tang

10

1 reference

9 August 2017

Jonathan J Ellis

11

1 reference

9 August 2017

Jeffrey Reid

12

1 reference

9 August 2017

Victoria Zismann

13

1 reference

9 August 2017

Irene Newsham

16

1 reference

9 August 2017

YuanQing Wu

17

1 reference

9 August 2017

Jane M Palmer

18

1 reference

9 August 2017

Thomas Pollak

19

1 reference

9 August 2017

David Youngkin

20

1 reference

9 August 2017

Bradford R Brooks

21

1 reference

9 August 2017

Catherine Lanagan

22

1 reference

9 August 2017

Hongwei Yin

26

1 reference

9 August 2017

Kevin M Brown

27

1 reference

9 August 2017

Richard Gibbs

28

1 reference

9 August 2017

language of work or name

English

0 references

publication date

25 December 2011

1 reference

9 August 2017

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9 August 2017

44

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9 August 2017

165-169

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9 August 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1038/ng.1041

9 August 2017

0 references

cites work

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Apoptosis signal-regulating kinase 1 in stress and immune response

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

MAP kinase signalling pathways in cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Patterns of somatic mutation in human cancer genomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

The consensus coding sequences of human breast and colorectal cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Mutations of the BRAF gene in human cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Haplo-insufficiency: a driving force in cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Redefining tumour suppressor genes: exceptions to the two-hit hypothesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267896

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

25 September 2018

1 reference

The UCSC Genome Browser database: update 2011

21 January 2018

1 reference

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

21 January 2018

1 reference

BFAST: an alignment tool for large scale genome resequencing

21 January 2018

1 reference

The Sequence Alignment/Map format and SAMtools

21 January 2018

1 reference

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

21 January 2018

1 reference

dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions

21 January 2018

1 reference

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

21 January 2018

1 reference

A method and server for predicting damaging missense mutations

21 January 2018

1 reference

Identification of deleterious mutations within three human genomes

21 January 2018

1 reference

MutationTaster evaluates disease-causing potential of sequence alterations

21 January 2018

1 reference

New Methods for Detecting Lineage-Specific Selection

21 January 2018

1 reference

PrimerZ: streamlined primer design for promoters, exons and human SNPs

21 January 2018

1 reference

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

21 January 2018

The Protein Data Bank

1 reference

Structural and Functional Characterization of the Human Protein Kinase ASK1

21 January 2018

1 reference

Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models

21 January 2018

1 reference

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

21 January 2018

1 reference

MUSTANG: a multiple structural alignment algorithm.

21 January 2018

1 reference

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NG.1041

1 reference

9 August 2017

1 reference

9 August 2017

1 reference