(Q35730784)

9 August 2017

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title

Immunotherapeutic uses of CpG oligodeoxynucleotides (English)

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9 August 2017

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Dennis M Klinman

1

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9 August 2017

1 April 2004

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Nature Reviews Immunology

9 August 2017

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9 August 2017

4

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9 August 2017

249-258

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9 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nri1329

9 August 2017

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Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

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31 March 2020

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CpG motifs in bacterial DNA trigger direct B-cell activation

31 March 2020

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

31 March 2020

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CpG-oligonucleotides for cancer immunotherapy : review of the literature and potential applications in malignant glioma

31 March 2020

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Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

31 March 2020

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

31 March 2020

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CpG ODN-mediated regulation of IL-12 p40 transcription

31 March 2020

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Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

31 March 2020

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31 March 2020

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Type I interferon-mediated stimulation of T cells by CpG DNA

31 March 2020

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

31 March 2020

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Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha

31 March 2020

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CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved

31 March 2020

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Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

31 March 2020

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Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

31 March 2020

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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

31 March 2020

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CpG oligodeoxynucleotides as vaccine adjuvants in primates

31 March 2020

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CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

31 March 2020

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Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates

31 March 2020

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Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma

31 March 2020

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Mammalian granulocyte-macrophage colony-stimulating factor and some CpG motifs have an effect on the immunogenicity of DNA and subunit vaccines in fish

31 March 2020

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Protection of chickens against Escherichia coli infections by DNA containing CpG motifs

31 March 2020

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Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection

31 March 2020

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Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.

31 March 2020

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Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms

31 March 2020

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CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism

31 March 2020

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CpG motifs as immune adjuvants

31 March 2020

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Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection

31 March 2020

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Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals

31 March 2020

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HIV-1/AIDS and the control of other infectious diseases in Africa

31 March 2020

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CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection

31 March 2020

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Pregnancy-associated depression of cell-mediated immunity.

31 March 2020

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Immunologic adaptations during pregnancy

31 March 2020

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Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

31 March 2020

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Th1-type immunity is incompatible with successful pregnancy

31 March 2020

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CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.

31 March 2020

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Competition between two steinernematid nematode species for an insect host at different soil depths

31 March 2020

1 reference

Preinfection treatment of resistant mice with CpG oligodeoxynucleotides renders them susceptible to friend retrovirus-induced leukemia

31 March 2020

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Sterically Stabilized Cationic Liposomes Improve the Uptake and Immunostimulatory Activity of CpG Oligonucleotides

31 March 2020

1 reference

CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus

31 March 2020

1 reference

CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

31 March 2020

1 reference

Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid

31 March 2020

1 reference

Amplification of antibody production by phosphorothioate oligodeoxynucleotides

31 March 2020

1 reference

Immunostimulatory DNA is a potent mucosal adjuvant

31 March 2020

1 reference

Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants

31 March 2020

1 reference

Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.

31 March 2020

1 reference

CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques.

31 March 2020

1 reference

Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis

31 March 2020

1 reference

Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant

31 March 2020

1 reference

CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea

31 March 2020

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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

31 March 2020

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Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea

31 March 2020

1 reference

The inverse association between tuberculin responses and atopic disorder.

31 March 2020

1 reference

Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

31 March 2020

1 reference

Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma

31 March 2020

1 reference

Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells

31 March 2020

1 reference

Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody

31 March 2020

1 reference

Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity

31 March 2020

1 reference

Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

31 March 2020

1 reference

DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice

31 March 2020

1 reference

Immunostimulatory DNA-based therapeutics for experimental and clinical allergy

31 March 2020

1 reference

Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity.

31 March 2020

1 reference

Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases

31 March 2020

1 reference

Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA.

31 March 2020

1 reference

Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.

31 March 2020

1 reference

Theoretical and experimental approaches to generalized autoimmunity

31 March 2020

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Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease

31 March 2020

1 reference

CpG DNA: a pathogenic factor in systemic lupus erythematosus?

31 March 2020

1 reference

Do DNA vaccines induce autoimmune disease?

31 March 2020

1 reference

Humoral and cellular immunity to an encoded protein induced by direct DNA injection

31 March 2020

1 reference

CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo

31 March 2020

1 reference

Chlamydia infections and heart disease linked through antigenic mimicry

31 March 2020

1 reference

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

31 March 2020

1 reference

Bacterial DNA causes septic shock

31 March 2020

1 reference

Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin.

31 March 2020

1 reference

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

31 March 2020

1 reference

DNA vaccines: safety and efficacy issues

31 March 2020

1 reference

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

31 March 2020

1 reference

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients.

31 March 2020

1 reference

Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease

31 March 2020

1 reference

31 March 2020

DNA vaccines: a review

1 reference

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant

31 March 2020

1 reference

CpG DNA as a vaccine adjuvant

31 March 2020

1 reference

Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis

31 March 2020

1 reference

The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines

31 March 2020

1 reference

Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: Adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides

31 March 2020

1 reference

Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant

31 March 2020

1 reference

Evaluation of adjuvants for protein vaccines against tuberculosis in guinea pigs.

31 March 2020

1 reference

Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in mice

31 March 2020

1 reference

Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability

31 March 2020

1 reference

Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes

31 March 2020

1 reference

DNA methylation and its possible biological roles

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1329

1 reference

PubMed ID

15057783

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

15057783