(Q35741596)

English

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

scientific article published on March 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Debabrata Mukhopadhyay

8

object named as

Debabrata Mukhopadhyay

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Europe PubMed Central

PubMed publication ID

10 August 2017

author name string

Deok-Beom Jung

1

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Europe PubMed Central

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10 August 2017

Miyong Yun

2

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10 August 2017

Eun-Ok Kim

3

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10 August 2017

Jaekwang Kim

4

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Europe PubMed Central

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10 August 2017

Bonglee Kim

5

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Europe PubMed Central

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10 August 2017

Ji Hoon Jung

6

1 reference

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10 August 2017

Enfeng Wang

7

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Edward Hammond

9

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Europe PubMed Central

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10 August 2017

Keith Dredge

10

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Europe PubMed Central

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10 August 2017

Viji Shridhar

11

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10 August 2017

Sung-Hoon Kim

12

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10 August 2017

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publication date

1 March 2015

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PubMed publication ID

10 August 2017

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Europe PubMed Central

PubMed publication ID

10 August 2017

6

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10 August 2017

7

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10 August 2017

4992-5004

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer

1 reference

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27 July 2018

Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells

1 reference

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27 July 2018

Aberrant expression of CXCR4 and β-catenin in pancreatic cancer.

1 reference

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27 July 2018

Target therapies in pancreatic carcinoma.

1 reference

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27 July 2018

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells

1 reference

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27 July 2018

Canonical wnt signaling is required for pancreatic carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Wnt/β-catenin signaling and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

The many faces and functions of β-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Heparanase Modulates Shh and Wnt3a Signaling in Human Medulloblastoma Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Nitric oxide-donating acetylsalicylic acid induces apoptosis in chronic lymphocytic leukemia cells and shows strong antitumor efficacy in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Syndecan-1: a dynamic regulator of the myeloma microenvironment

1 reference

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27 July 2018

Biology and management of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Cancer statistics, 2007

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Heparan sulfate regulation of progenitor cell fate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

27 July 2018

Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

1 reference

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27 July 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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27 July 2018

PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467129

25 September 2018

The heparanase system and tumor metastasis: is heparanase the seed and soil?

1 reference

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25 September 2018

Metastatic pancreatic cancer: is gemcitabine still the best standard treatment? (Review).

1 reference

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25 September 2018

Syndecans in tumor cell adhesion and signaling

1 reference

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25 September 2018

Identifiers

10.18632/ONCOTARGET.3214

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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