(Q35750835)

10 August 2017

1 reference

title

Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway (English)

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Gene Ontology release 2020-05-02

10 August 2017

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David R Evans

1

1 reference

PubMed ID

15096496

10 August 2017

Hedeel I Guy

series ordinal

2

1 reference

PubMed ID

15096496

10 August 2017

language of work or name

English

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publication date

19 April 2004

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Journal of Biological Chemistry

10 August 2017

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10 August 2017

279

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10 August 2017

33035-33038

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10 August 2017

32

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

10 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Physiological concentrations of purines and pyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Uridine and its nucleotides: biological actions, therapeutic potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Recent advances in the molecular biology of nucleoside transporters of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Ordered biochemical program of gene expression in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Pyrimidine nucleotide synthesis in the rat kidney in early diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Leflunomide for the treatment of rheumatoid arthritis and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

The gene coding for carbamoyl-phosphate synthetase I was formed by fusion of an ancestral glutaminase gene and a synthetase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Mechanism of Carbamoyl-Phosphate Synthetase. Properties of the Two Binding Sites for ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

The aspartate transcarbamylase domain of a mammalian multifunctional protein expressed as an independent enzyme in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Comparative modeling of mammalian aspartate transcarbamylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Substitutions in the aspartate transcarbamoylase domain of hamster CAD disrupt oligomeric structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

An evolutionary treasure: unification of a broad set of amidohydrolases related to urease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Cloning, overexpression, and characterization of the functional dihydroorotase domain of the mammalian multifunctional protein CAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Dependence of the catalytic activities on the aggregation and conformation states of uridine 5'-phosphate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Cell cycle-dependent regulation of pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Regulation of CAD gene expression in mouse fibroblasts during the transition from the resting to the growing state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Myc versus USF: discrimination at the cad gene is determined by core promoter elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Required allosteric effector site for N-acetylglutamate on carbamoyl-phosphate synthetase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

A mutation that uncouples allosteric regulation of carbamyl phosphate synthetase in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Regulation of carbamoyl phosphate synthetase by MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

Photoaffinity Labeling with the Activator IMP and Site-Directed Mutagenesis of Histidine 995 of Carbamoyl Phosphate Synthetase fromEscherichia coliDemonstrate That the Binding Site for IMP Overlaps with That for the Inhibitor UMP†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R400007200

21 January 2018

Identifiers

DOI

10.1074/JBC.R400007200

1 reference

10 August 2017

1 reference

PubMed ID

15096496