(Q35759089)

10 August 2017

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title

P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease (English)

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10 August 2017

M. Murray

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1511529

3 October 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1511529

3 October 2022

publication date

1 August 1992

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Clinical Pharmacokinetics

10 August 2017

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10 August 2017

23

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10 August 2017

132-146

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10 August 2017

2

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https://scigraph.springernature.com/pub.10.2165/00003088-199223020-00005

10 August 2017

0 references

cites work

Potent Inhibition of Cytochrome P450IID6 (Debrisoquin 4-Hydroxylase) by Flecainide In Vitro and In Vivo

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12 December 2020

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1 reference

12 December 2020

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1 reference

12 December 2020

Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem

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12 December 2020

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

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12 December 2020

Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.

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12 December 2020

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

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12 December 2020

Interaction with the pharmacokinetics of ethinylestradiol and progestogens contained in oral contraceptives

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12 December 2020

Delayed clearance of diazepam due to cimetidine.

1 reference

12 December 2020

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

1 reference

12 December 2020

Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism

1 reference

12 December 2020

Drug disposition and liver disease

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12 December 2020

Pharmacokinetics of nifedipine after oral administration in chronic liver disease

1 reference

12 December 2020

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

1 reference

12 December 2020

N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives

1 reference

12 December 2020

Genetic variation in the human hepatic cytochrome P-450 system

1 reference

12 December 2020

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1 reference

12 December 2020

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1 reference

12 December 2020

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1 reference

12 December 2020

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

1 reference

12 December 2020

Fluoxetine and norfluoxetine are potent inhibitors of P450IID6--the source of the sparteine/debrisoquine oxidation polymorphism

1 reference

12 December 2020

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

1 reference

12 December 2020

Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans

1 reference

12 December 2020

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene

1 reference

12 December 2020

cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)

1 reference

12 December 2020

Polymorphism of carbon oxidation of drugs and clinical implications

1 reference

12 December 2020

The genetic controlof bufuralol metabolisminman

1 reference

12 December 2020

Cimetidine and bioavailability of propranolol

1 reference

12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

1 reference

12 December 2020

Effects of methoxsalen on the metabolism of acetaminophen in humans

1 reference

12 December 2020

The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine

1 reference

12 December 2020

Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers

1 reference

12 December 2020

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1 reference

12 December 2020

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

1 reference

12 December 2020

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

1 reference

12 December 2020

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives

1 reference

12 December 2020

Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).

1 reference

12 December 2020

Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites

1 reference

12 December 2020

The genetic defect of mephenytoin hydroxylation

1 reference

12 December 2020

Drug interactions with cimetidine: an update

1 reference

12 December 2020

Inhibition of alfentanil metabolism by erythromycin.

1 reference

12 December 2020

Polymorphic hydroxylation of perhexiline maleate in man.

1 reference

12 December 2020

Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation

1 reference

12 December 2020

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1 reference

12 December 2020

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

12 December 2020

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1 reference

12 December 2020

E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

Cimetidine Potentiation of the Hypoprothrombinemic Effect of Warfarin

1 reference

12 December 2020

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

1 reference

12 December 2020

Downregulation of the male-specific hepatic microsomal steroid 16 alpha-hydroxylase, cytochrome P-450UT-A, in rats with portal bypass. Relevance to estradiol accumulation and impaired drug metabolism in hepatic cirrhosis

1 reference

12 December 2020

Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man.

1 reference

12 December 2020

Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family

1 reference

12 December 2020

The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition

1 reference

12 December 2020

Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide

1 reference

12 December 2020

Inhibition and induction of theophylline metabolism by 8-methoxypsoralen. In vivo study in rats and humans.

1 reference

12 December 2020

Methoxyphenamine and dextromethorphan as safe probes for debrisoquine hydroxylation polymorphism

1 reference

12 December 2020

Sequence of a human liver cytochrome P-450 cDNA clone

1 reference

12 December 2020

Influence of genetic polymorphism on the metabolism and disposition of encainide in man

1 reference

12 December 2020

Studies on the mechanism of denaturation of cytochrome P-450 by cyclophosphamide and its metabolites

1 reference

12 December 2020

Altered regulation of cytochrome P-450 enzymes in choline-deficient cirrhotic male rat liver: impaired regulation and activity of the male-specific androst-4-ene-3,17-dione 16 alpha-hydroxylase, cytochrome P-450UT-A, in hepatic cirrhosis

1 reference

12 December 2020

Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies

1 reference

12 December 2020

Comparative effects of antithrombitic and antimycotic N-substituted imidazoles on rat hepatic microsomal steroid and xenobiotic hydroxylases in vitro

1 reference

12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

12 December 2020

Cimetidine interaction with phenytoin

1 reference

12 December 2020

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

1 reference

12 December 2020

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

1 reference

12 December 2020

A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing

1 reference

12 December 2020

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1 reference

12 December 2020

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes

1 reference

12 December 2020

In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes

1 reference

12 December 2020

Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.

1 reference

12 December 2020

Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism

1 reference

12 December 2020

Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation

1 reference

12 December 2020

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1 reference

12 December 2020

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes

1 reference

12 December 2020

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1 reference

12 December 2020

Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing

1 reference

12 December 2020

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

1 reference

12 December 2020

Drug interactions with quinolones

1 reference

12 December 2020

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1 reference

12 December 2020

Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody

1 reference

12 December 2020

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.

1 reference

12 December 2020

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme

1 reference

12 December 2020

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

1 reference

12 December 2020

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.

1 reference

12 December 2020

Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol

1 reference

12 December 2020

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

1 reference

12 December 2020

Acute and chronic studies of diltiazem in elderly versus young hypertensive patients

1 reference

12 December 2020

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

1 reference

12 December 2020

Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Genetic polymorphism of phenformin 4-hydroxylation

1 reference

12 December 2020

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1 reference

12 December 2020

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily

1 reference

12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

Secobarbital-mediated inactivation of rat liver cytochrome P-450b: a mechanistic reappraisal.

1 reference

12 December 2020

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450

1 reference

12 December 2020

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1 reference

12 December 2020

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction

1 reference

12 December 2020

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

1 reference

12 December 2020

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver

1 reference

12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1 reference

12 December 2020

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1 reference

12 December 2020

Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics

1 reference

12 December 2020

Effect of liver regeneration on hepatic cytochrome P450 isozymes and serum sex steroids in the male rat

1 reference

12 December 2020

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

1 reference

12 December 2020

Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

12 December 2020

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man

1 reference

12 December 2020

Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes

1 reference

12 December 2020

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

1 reference

12 December 2020

Imidazole derivatives—A new class of microsomal enzyme inhibitors

1 reference

12 December 2020

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression

1 reference

12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

1 reference

12 December 2020

Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products

1 reference

12 December 2020

Impaired androgen 16 alpha-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats

1 reference

12 December 2020

Influence of DH/DL alleles regulating debrisoquine oxidation on phenytoin hydroxylation

1 reference

12 December 2020

Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies

1 reference

12 December 2020

Inhibition of theophylline clearance by troleandomycin

1 reference

12 December 2020

10.2165/00003088-199223020-00005

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

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