(Q35774046)

10 August 2017

title

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease (English)

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10 August 2017

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9

Annalisa Pastore

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10 August 2017

6

Geoff Kelly

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10 August 2017

Thomas L Williams

2

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Kris Pauwels

object named as

Kris Pauwels

1

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Louise Serpell

object named as

Louise C Serpell

10

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Joost Schymkowitz

object named as

Joost Schymkowitz

7

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author name string

Kyle L Morris

3

1 reference

10 August 2017

Wim Jonckheere

4

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10 August 2017

Annelies Vandersteen

5

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10 August 2017

Frederic Rousseau

8

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10 August 2017

Kerensa Broersen

11

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10 August 2017

language of work or name

English

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publication date

8 December 2011

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10 August 2017

number of pages

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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10 August 2017

volume

287

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10 August 2017

issue

8

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10 August 2017

page(s)

5650-5660

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A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

10 August 2017

cites work

1 reference

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Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

12 July 2018

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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

12 July 2018

1 reference

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Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

12 July 2018

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Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease

12 July 2018

1 reference

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The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

12 July 2018

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

12 July 2018

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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

12 July 2018

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Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions

12 July 2018

1 reference

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Plasticity of amyloid fibrils

12 July 2018

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Structures for amyloid fibrils

12 July 2018

1 reference

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

12 July 2018

1 reference

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Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

12 July 2018

1 reference

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

12 July 2018

1 reference

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

12 July 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

12 July 2018

1 reference

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Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.

12 July 2018

1 reference

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

12 July 2018

1 reference

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

12 July 2018

1 reference

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

12 July 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

12 July 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

12 July 2018

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Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

12 July 2018

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X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation

12 July 2018

1 reference

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Surface plasmon resonance analysis of Alzheimer's beta-amyloid aggregation on a solid surface: from monomers to fully-grown fibrils.

12 July 2018

1 reference

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Abeta40 inhibits amyloid deposition in vivo.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285338

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

25 September 2018

1 reference

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Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.

25 September 2018

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The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

25 September 2018

1 reference

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Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy

25 September 2018

1 reference

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Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285338

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285338

Structure and texture of fibrous crystals formed by Alzheimer's abeta(11-25) peptide fragment

25 September 2018

1 reference

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Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

25 September 2018

1 reference

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Neurodegenerative disease: amyloid pores from pathogenic mutations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285338

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285338

Using inducible vectors to study intracellular trafficking of GFP-tagged steroid/nuclear receptors in living cells

25 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.264473

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.264473

CLEARER: a new tool for the analysis of X-ray fibre diffraction patterns and diffraction simulation from atomic structural models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.264473

Isotope-filtered 2D NMR of a protein-peptide complex: study of a skeletal muscle myosin light chain kinase fragment bound to calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.264473

Abeta40 protects non-toxic Abeta42 monomer from aggregation

21 January 2018

1 reference

12 December 2020

Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates

1 reference

12 December 2020

X-ray diffraction studies on amyloid filaments

1 reference

12 December 2020

Analysis of fibril elongation using surface plasmon resonance biosensors

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.264473

1 reference

10 August 2017

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10 August 2017

1 reference