(Q35787276)

10 August 2017

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title

Targeting multiple signal transduction pathways through inhibition of Hsp90. (English)

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10 August 2017

Hong Zhang

1

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10 August 2017

Francis Burrows

series ordinal

2

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10 August 2017

publication date

27 May 2004

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Journal of Molecular Medicine

10 August 2017

published in

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10 August 2017

volume

82

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10 August 2017

issue

8

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10 August 2017

page(s)

488-499

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Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

10 August 2017

cites work

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12 December 2020

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

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12 December 2020

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures

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12 December 2020

Modulation of Akt kinase activity by binding to Hsp90

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12 December 2020

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

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12 December 2020

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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12 December 2020

Growth factor receptors as molecular targets for cancer diagnosis and therapy

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12 December 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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12 December 2020

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

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12 December 2020

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

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12 December 2020

Imatinib: a targeted clinical drug development

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12 December 2020

Discovery of a novel Raf kinase inhibitor

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12 December 2020

Inhibiting tyrosine kinases: successes and limitations

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12 December 2020

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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12 December 2020

Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts

1 reference

12 December 2020

Regulation of beta-catenin function by the IkappaB kinases

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12 December 2020

Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts

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12 December 2020

Mutations of the BRAF gene in human cancer

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12 December 2020

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

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12 December 2020

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

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12 December 2020

Wnt signaling and cancer

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

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12 December 2020

FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.

1 reference

12 December 2020

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

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12 December 2020

ATPases as drug targets: learning from their structure

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12 December 2020

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

1 reference

12 December 2020

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Structure and functional relationships of Hsp90.

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12 December 2020

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

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12 December 2020

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

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12 December 2020

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

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12 December 2020

Clinical development of mammalian target of rapamycin inhibitors

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12 December 2020

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

12 December 2020

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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12 December 2020

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

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12 December 2020

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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12 December 2020

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

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12 December 2020

The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

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12 December 2020

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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12 December 2020

The role of FLT3 in haematopoietic malignancies

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12 December 2020

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

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12 December 2020

Heat shock protein 90.

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12 December 2020

Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.

1 reference

12 December 2020

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

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12 December 2020

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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12 December 2020

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

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12 December 2020

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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12 December 2020

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

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12 December 2020

BAY 43-9006: preclinical data

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12 December 2020

Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells

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12 December 2020

Stereospecific antitumor activity of radicicol oxime derivatives

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12 December 2020

HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer.

1 reference

12 December 2020

Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4

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12 December 2020

Activity of the Raf kinase inhibitor BAY 43-9006 in patients with advanced solid tumors

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12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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12 December 2020

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

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12 December 2020

Differential heat stress stability of epidermal growth factor receptor and erbB-2 receptor tyrosine kinase activities

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12 December 2020

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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12 December 2020

Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer

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12 December 2020

BRAF Mutation in Papillary Thyroid Carcinoma

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12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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12 December 2020

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy

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12 December 2020

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

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12 December 2020

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

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12 December 2020

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12 December 2020

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia

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12 December 2020

Suppression of RAS and MOS transformation by radicicol.

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12 December 2020

Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD–transformed hematopoietic cells

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12 December 2020

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

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12 December 2020

Regulation of the c-Abl and Bcr-Abl tyrosine kinases

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12 December 2020

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

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12 December 2020

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

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12 December 2020

Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis

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12 December 2020

Targeting mTOR signaling for cancer therapy

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12 December 2020

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

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12 December 2020

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol

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12 December 2020

Geldanamycin, a new antibiotic

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12 December 2020

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

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12 December 2020

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

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12 December 2020

10.1007/S00109-004-0549-9

Identifiers

DOI

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10 August 2017

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