(Q35794541)

10 August 2017

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title

Proteomic approach to studying Parkinson's disease (English)

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10 August 2017

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2

David R Goodlett

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10 August 2017

Jing Zhang

1

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10 August 2017

publication date

1 June 2004

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10 August 2017

published in

Molecular Neurobiology

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10 August 2017

volume

29

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10 August 2017

issue

3

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10 August 2017

page(s)

271-288

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The 26S proteasome: a molecular machine designed for controlled proteolysis

10 August 2017

cites work

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12 December 2020

Identification of novel candidates for replicative senescence by functional proteomics.

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12 December 2020

Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine

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12 December 2020

Weighing naked proteins: practical, high-accuracy mass measurement of peptides and proteins

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12 December 2020

Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells

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12 December 2020

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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12 December 2020

Failure of the ubiquitin-proteasome system in Parkinson's disease

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12 December 2020

Central depletion of dopamine in rats by 1-methyl-4-phenylpyridine

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12 December 2020

Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine

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12 December 2020

Degradation of oxidized proteins by the 20S proteasome.

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12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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12 December 2020

Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate

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12 December 2020

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

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12 December 2020

Direct analysis of protein complexes using mass spectrometry

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12 December 2020

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

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12 December 2020

Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain

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12 December 2020

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

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12 December 2020

Chaperoning brain diseases

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12 December 2020

Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.

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12 December 2020

In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+

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12 December 2020

Differential stable isotope labeling of peptides for quantitation and de novo sequence derivation.

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12 December 2020

Aggresomes: a cellular response to misfolded proteins

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12 December 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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12 December 2020

Altered proteasomal function in sporadic Parkinson's disease

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12 December 2020

The rat liver mitochondrial proteins

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12 December 2020

Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses

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12 December 2020

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

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12 December 2020

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

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12 December 2020

Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes.

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12 December 2020

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

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12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

The proteasome, a novel protease regulated by multiple mechanisms

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12 December 2020

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Identification of nuclei associated proteins by 2D-gel electrophoresis and mass spectrometry

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12 December 2020

Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease.

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12 December 2020

Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity.

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12 December 2020

Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus

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12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

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12 December 2020

Age at onset in two common neurodegenerative diseases is genetically controlled

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12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

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12 December 2020

Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase

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12 December 2020

Mitochondrial oxidative phosphorylation system assembly in man: recent achievements

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12 December 2020

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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12 December 2020

Opening doors into the proteasome.

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12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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12 December 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Mass spectrometry in proteomics

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12 December 2020

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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12 December 2020

Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.

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12 December 2020

"Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders.

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12 December 2020

Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment

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12 December 2020

In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.

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12 December 2020

Simplification of complex peptide mixtures for proteomic analysis: reversible biotinylation of cysteinyl peptides

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12 December 2020

The role of alpha-synuclein in Parkinson's disease: insights from animal models

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12 December 2020

Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

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12 December 2020

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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12 December 2020

Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease

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12 December 2020

The mitochondrial common deletion in Parkinson's disease and related movement disorders

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12 December 2020

1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Genetic and environmental factors in the cause of Parkinson's disease

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

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12 December 2020

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

The yeast nuclear pore complex: composition, architecture, and transport mechanism

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12 December 2020

Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death

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12 December 2020

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

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12 December 2020

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro

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12 December 2020

MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

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12 December 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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12 December 2020

Selective destruction of dopaminergic neurons by low concentrations of 6-OHDA and MPP+: protection by acetylsalicylic acid aspirin

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12 December 2020

In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity

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12 December 2020

Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

Origin and functional consequences of the complex I defect in Parkinson's disease

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12 December 2020

Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein

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12 December 2020

Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo

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12 December 2020

Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

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12 December 2020

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

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12 December 2020

Chaperone-mediated protein folding

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12 December 2020

Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

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12 December 2020

A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition

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12 December 2020

In vivo generation of hydrogen peroxide from 6-hydroxydopamine

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12 December 2020

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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12 December 2020

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

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12 December 2020

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

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12 December 2020

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

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12 December 2020

Effects of nerve growth factor infusion on behavioral recovery and graft survival following intraventricular adrenal medulla grafts in the unilateral 6-hydroxydopamine lesioned rat.

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12 December 2020

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12 December 2020

Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study.

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12 December 2020

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12 December 2020

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

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12 December 2020

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

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12 December 2020

Lipid Peroxidation in Brain: Interactions of L-DOPA/Dopamine with Ascorbate and Iron

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12 December 2020

Recent developments in the pathology of Parkinson's disease

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12 December 2020

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

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12 December 2020

Large-scale proteomic analysis of the human spliceosome

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12 December 2020

Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

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12 December 2020

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

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12 December 2020

A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis

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12 December 2020

Autosomal dominant Parkinson's disease

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12 December 2020

Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity

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12 December 2020

Understanding cell death in Parkinson's disease

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12 December 2020

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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12 December 2020

Aging, energy, and oxidative stress in neurodegenerative diseases.

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12 December 2020

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

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12 December 2020

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

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12 December 2020

The ubiquitin pathway in Parkinson's disease

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12 December 2020

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

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12 December 2020

Neurotoxicity of endogenous cysteinylcatechols

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12 December 2020

Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease

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12 December 2020

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders

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12 December 2020

Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease

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12 December 2020

6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease

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12 December 2020

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

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12 December 2020

Free radicals in the physiological control of cell function

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

Cerebrospinal dopamine metabolites in rats after intrastriatal administration of 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion

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12 December 2020

Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase

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12 December 2020

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease

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12 December 2020

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

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12 December 2020

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

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12 December 2020

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

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12 December 2020

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

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12 December 2020

Abnormalities of cerebral oxidative metabolism in animal models of Parkinson disease

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12 December 2020

Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue

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12 December 2020

Proteomics without polyacrylamide: qualitative and quantitative uses of tandem mass spectrometry in proteome analysis

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12 December 2020

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

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12 December 2020

Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to Parkinson's disease

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12 December 2020

Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.

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12 December 2020

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

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12 December 2020

alpha-synuclein and cytosolic dopamine: stabilizing a bad situation

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12 December 2020

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases

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12 December 2020

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

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12 December 2020

Proteome profiling-pitfalls and progress

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12 December 2020

The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence

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12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

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12 December 2020

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

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12 December 2020

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

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12 December 2020

Neurochemical responses to 6-hydroxydopamine and L-dopa therapy: implications for Parkinson's disease

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12 December 2020

Applied proteomics: mitochondrial proteins and effect on function

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12 December 2020

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

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12 December 2020

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12 December 2020

A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease

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12 December 2020

Heavy metals and the etiology of Parkinson's disease and other movement disorders

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12 December 2020

Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome

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12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

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12 December 2020

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12 December 2020

Model experiments on the molecular mechanism of action of 6-hydroxydopamine

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12 December 2020

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice

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12 December 2020

Origin and persistence of the mitochondrial genome

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12 December 2020

A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology

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12 December 2020

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

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12 December 2020

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

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12 December 2020

Structural and functional characterization of 20S and 26S proteasomes from bovine brain.

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12 December 2020

N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats.

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12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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12 December 2020

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

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12 December 2020

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

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12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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12 December 2020

Identifiers

DOI

10.1385/MN:29:3:271

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Dimensions Publication ID

10 August 2017

1046884102

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