(Q35799985)

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Structural insights into the signal recognition particle

scientific article published on January 2004

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Europe PubMed Central

10 August 2017

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Europe PubMed Central

title

Structural insights into the signal recognition particle (English)

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stated in

Europe PubMed Central

10 August 2017

1

Jennifer A Doudna

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stated in

Europe PubMed Central

10 August 2017

Robert T Batey

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publication date

1 January 2004

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stated in

Europe PubMed Central

10 August 2017

19

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Annual Review of Biochemistry

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stated in

Europe PubMed Central

10 August 2017

73

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stated in

Europe PubMed Central

10 August 2017

539-557

1 reference

stated in

Europe PubMed Central

10 August 2017

Hierarchical assembly of the Alu domain of the mammalian signal recognition particle

1 reference

9 October 2022

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Conformational variability of the N-terminal helix in the structure of ribosomal protein S15

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9 October 2022

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The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Visualizing induced fit in early assembly of the human signal recognition particle

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9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Protein-protein, protein-RNA and protein-lipid interactions of signal-recognition particle components in the hyperthermoacidophilic archaeon Acidianus ambivalens

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Mutations in the gene for EF-G reduce the requirement for 4.5S RNA in the growth of E. coli

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure and assembly of the Alu domain of the mammalian signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The signal recognition particle of Archaea

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Anionic phospholipids are involved in membrane association of FtsY and stimulate its GTPase activity

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Induced nucleotide specificity in a GTPase

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the ribonucleoprotein core of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of an early protein-RNA assembly complex of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Substrate twinning activates the signal recognition particle and its receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the NG domain from the signal-recognition particle receptor FtsY

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the conserved GTPase domain of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Functional characterization of recombinant chloroplast signal recognition particle.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

A universal mode of helix packing in RNA.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crosslinking of 4.5S RNA to the Escherichia coli ribosome in the presence or absence of the protein Ffh.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Systematic site-directed mutagenesis of human protein SRP54: interactions with signal recognition particle RNA and modes of signal peptide recognition

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Evidence for a novel GTPase priming step in the SRP protein targeting pathway

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Induced structural changes of 7SL RNA during the assembly of human signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the signal recognition particle by electron microscopy

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the signal sequence binding subunit of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the most conserved internal loop in SRP RNA

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

S-domain assembly of the signal recognition particle.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Prediction of signal recognition particle RNA genes

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Distinct modes of signal recognition particle interaction with the ribosome

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

3D domain swapping: as domains continue to swap

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

RNA tertiary interactions in the large ribosomal subunit: the A-minor motif

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Heterodimeric GTPase Core of the SRP Targeting Complex

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the SRP19 RNA complex and implications for signal recognition particle assembly

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure, function and evolution of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Signal Recognition Particle (SRP)-mediated Targeting and Sec-dependent Translocation of an ExtracellularEscherichia coliProtein

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Function of a chloroplast SRP in thylakoid protein export

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Role of SRP RNA in the GTPase cycles of Ffh and FtsY.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

SRPDB: Signal Recognition Particle Database

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The structural basis of protein targeting and translocation in bacteria.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Genetic selection and DNA sequences of 4.5S RNA homologs

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Role of SRP19 in assembly of the Archaeoglobus fulgidus signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The N-domain of the signal recognition particle 54-kDa subunit promotes efficient signal sequence binding

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

A compact RNA tertiary structure contains a buried backbone-K+ complex

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Fluorescence analysis of tryptophan-containing variants of the LamB signal sequence upon insertion into a lipid bilayer

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Membrane association of FtsY, the E. coli SRP receptor

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Decreased requirement for 4.5S RNA in 16S and 23S rRNA mutants of Escherichia coli.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

The functioning of the SRP receptor FtsY in protein-targeting in E. coli is correlated with its ability to bind and hydrolyse GTP.

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.73.011303.074048

Identifiers

DOI

10.1146/ANNUREV.BIOCHEM.73.011303.074048

1 reference

stated in

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

PubMed ID

15189152

retrieved

10 August 2017

ResearchGate publication ID

8518465

0 references

(Q35799985)

Structural insights into the signal recognition particle

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