(Q35869639)

10 August 2017

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title

Pathogenetic mechanisms of parkin in Parkinson's disease (English)

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10 August 2017

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1

Nobutaka Hattori

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10 August 2017

2

Yoshikuni Mizuno

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PubMed ID

15325839

10 August 2017

language of work or name

English

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publication date

1 August 2004

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10 August 2017

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10 August 2017

364

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10 August 2017

722-724

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10 August 2017

9435

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

10 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Molecular genetic analysis of a novelParkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in theParkin gene in affected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin mutations are frequent in patients with isolated early-onset parkinsonism.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin disease: a phenotypic study of a large case series

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Functional association of the parkin gene promoter with idiopathic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

How much phenotypic variation can be attributed to parkin genotype?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

SEPT5_v2 is a parkin-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin is associated with actin filaments in neuronal and nonneural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin is recruited to the centrosome in response to inhibition of proteasomes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916901-8

7 January 2021

10.1016/S0140-6736(04)16901-8

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15325839