(Q35877199)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

review article

1 reference

title

Tolerance, not immunity, crucially depends on IL-2 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Thomas R Malek

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

publication date

1 September 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

1 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

665-674

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15343366%20AND%20SRC:MED&resulttype=core&format=json

The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis

1 January 2020

cites work

1 reference

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

31 March 2020

1 reference

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

31 March 2020

1 reference

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

31 March 2020

1 reference

Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain

31 March 2020

1 reference

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

31 March 2020

1 reference

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

31 March 2020

1 reference

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

31 March 2020

1 reference

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

31 March 2020

1 reference

In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells

31 March 2020

1 reference

Structure and expression of a cloned cDNA for human interleukin-2.

31 March 2020

1 reference

Regulatory T cells in autoimmmunity*.

31 March 2020

1 reference

Regulatory T cells: key controllers of immunologic self-tolerance

31 March 2020

1 reference

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

31 March 2020

1 reference

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

31 March 2020

1 reference

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.

31 March 2020

1 reference

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

31 March 2020

1 reference

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

31 March 2020

1 reference

Interleukin-2 is indispensable for development of immunological self-tolerance

31 March 2020

1 reference

Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo

31 March 2020

1 reference

Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

31 March 2020

1 reference

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

31 March 2020

1 reference

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

31 March 2020

1 reference

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.

31 March 2020

1 reference

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

31 March 2020

1 reference

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

31 March 2020

1 reference

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

31 March 2020

1 reference

Activation requirements for the induction of CD4+CD25+ T cell suppressor function

31 March 2020

1 reference

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

31 March 2020

1 reference

Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

31 March 2020

1 reference

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

31 March 2020

1 reference

Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells

31 March 2020

1 reference

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

31 March 2020

1 reference

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

31 March 2020

1 reference

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

31 March 2020

1 reference

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

31 March 2020

1 reference

Control of regulatory T cell development by the transcription factor Foxp3

31 March 2020

1 reference

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

1 reference

An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

1 reference

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

1 reference

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

31 March 2020

1 reference

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

1 reference

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

31 March 2020

1 reference

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

31 March 2020

1 reference

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

31 March 2020

1 reference

31 March 2020

1 reference

Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells

31 March 2020

1 reference

Evidence for an interleukin-independent pathway for human lymphocyte activation

31 March 2020

1 reference

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

31 March 2020

1 reference

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules

31 March 2020

1 reference

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

31 March 2020

1 reference

CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression

31 March 2020

1 reference

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

31 March 2020

1 reference

Interleukin 2 plays a central role in Th2 differentiation.

31 March 2020

1 reference

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

1 reference

Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.

31 March 2020

1 reference

Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

31 March 2020

1 reference

Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.

31 March 2020

1 reference

Immune responses in interleukin-2-deficient mice

31 March 2020

1 reference

Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant

31 March 2020

1 reference

Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice

31 March 2020

1 reference

IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion

31 March 2020

1 reference

Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo

31 March 2020

1 reference

Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses.

31 March 2020

1 reference

Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors

31 March 2020

1 reference

Generation and analysis of interleukin-4 deficient mice

31 March 2020

1 reference

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

31 March 2020

1 reference

Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool.

31 March 2020

1 reference

Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death

31 March 2020

1 reference

IL-15 and IL-2: a matter of life and death for T cells in vivo

31 March 2020

1 reference

Costimulation of T cells by OX40, 4-1BB, and CD27.

31 March 2020

1 reference

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

31 March 2020

1 reference

Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation.

31 March 2020

1 reference

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

31 March 2020

1 reference

Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

31 March 2020

1 reference

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

31 March 2020

1 reference

Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

31 March 2020

1 reference

Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population

31 March 2020

1 reference

CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

1 reference

Human IL-2 receptor alpha chain deficiency

31 March 2020

1 reference

Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial

31 March 2020

1 reference

Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus

31 March 2020

1 reference

Interleukin-2: clinical applications

31 March 2020

1 reference

Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

31 March 2020

1 reference

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

31 March 2020

1 reference

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

31 March 2020

1 reference

IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation

31 March 2020

1 reference

Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease

31 March 2020

1 reference

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

31 March 2020

1 reference

Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

31 March 2020

1 reference

Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation

31 March 2020

1 reference

CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression

31 March 2020

1 reference

Clinical advances in therapies targeting the interleukin-2 receptor

31 March 2020

1 reference

The use of antibodies against the IL-2 receptor in transplantation

31 March 2020

1 reference

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

31 March 2020

1 reference

Biology of the interleukin-2 receptor

31 March 2020

1 reference