(Q35930703)

11 August 2017

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title

Post-translational modification of p53 in tumorigenesis (English)

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11 August 2017

1

Ann M Bode

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11 August 2017

Zigang Dong

2

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PubMed ID

15510160

11 August 2017

language of work or name

English

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publication date

1 October 2004

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11 August 2017

Nature Reviews Cancer

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11 August 2017

4

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11 August 2017

793-805

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11 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrc1455

11 August 2017

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cites work

Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome.

1 reference

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

A decade of tyrosine kinases: from gene discovery to therapeutics

21 January 2018

1 reference

ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified

21 January 2018

1 reference

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

Deacetylation of p53 modulates its effect on cell growth and apoptosis

21 January 2018

1 reference

Histone deacetylases specifically down-regulate p53-dependent gene activation

21 January 2018

1 reference

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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Allosteric activation of latent p53 tetramers

21 January 2018

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Phosphorylation of human p53 on Thr-55.

21 January 2018

1 reference

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53.

21 January 2018

1 reference

p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells.

21 January 2018

1 reference

Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

21 January 2018

1 reference

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

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In vitro analysis of the dominant negative effect of p53 mutants

21 January 2018

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How many mutant p53 molecules are needed to inactivate a tetramer?

21 January 2018

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Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

21 January 2018

1 reference

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes

21 January 2018

1 reference

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase

21 January 2018

1 reference

Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract

21 January 2018

1 reference

The transcriptional role of PML and the nuclear body

21 January 2018

1 reference

The function of PML in p53-dependent apoptosis

21 January 2018

1 reference

Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies

21 January 2018

1 reference

Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot

21 January 2018

1 reference

Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus

21 January 2018

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

21 January 2018

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

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The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation

21 January 2018

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

21 January 2018

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SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

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MDM2-ARF complex regulates p53 sumoylation

21 January 2018

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P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.

21 January 2018

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Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

21 January 2018

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Mdm2 association with p53 targets its ubiquitination

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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Hypophosphorylation of Mdm2 augments p53 stability

21 January 2018

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification

21 January 2018

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The genetic defect in ataxia-telangiectasia

21 January 2018

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Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

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Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues

21 January 2018

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

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A dynamic role of HAUSP in the p53-Mdm2 pathway

21 January 2018

1 reference

Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

21 January 2018

1 reference

Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

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Requirement of ATM in UVA-induced signaling and apoptosis.

21 January 2018

1 reference

Preferential binding of ATR protein to UV-damaged DNA.

21 January 2018

1 reference

General keynote: the impact of cancer chemoprevention

21 January 2018

1 reference

Inhibition of B16BL6 tumor progression by coadministration of recombinant angiostatin K1-3 and endostatin genes with cationic liposomes

21 January 2018

1 reference

Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involved

21 January 2018

1 reference

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

21 January 2018

1 reference

Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells

21 January 2018

1 reference

Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases.

21 January 2018

1 reference

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

21 January 2018

1 reference

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

21 January 2018

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Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

21 January 2018

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Inhibition of p53 degradation by Mdm2 acetylation

21 January 2018

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MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation

21 January 2018

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

21 January 2018

1 reference

Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival

21 January 2018

1 reference

p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

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Deconstructing PML-induced premature senescence

21 January 2018

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PML is a direct p53 target that modulates p53 effector functions

21 January 2018

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MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

1 reference

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

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The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

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COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

21 January 2018

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Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

21 January 2018

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

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The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage

21 January 2018

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The negative role of cyclin G in ATM-dependent p53 activation

21 January 2018

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Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.

21 January 2018

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21 January 2018

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Nucleophosmin sets a threshold for p53 response to UV radiation

21 January 2018

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

21 January 2018

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Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

21 January 2018

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

21 January 2018

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Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin

21 January 2018

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A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

21 January 2018

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

21 January 2018

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

21 January 2018

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

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Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20.

21 January 2018

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

21 January 2018

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Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

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The p53 protein is an unusually shaped tetramer that binds directly to DNA.

21 January 2018

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

31 March 2020

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Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

31 March 2020

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Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53

31 March 2020

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Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

31 March 2020

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Hepatitis C virus core protein: intriguing properties and functional relevance

31 March 2020

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The gain of function of the p53 mutant Asp281Gly is dependent on its ability to form tetramers

31 March 2020

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Distinct pattern of p53 phosphorylation in human tumors

31 March 2020

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Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

31 March 2020

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Ser392 phosphorylation regulates the oncogenic function of mutant p53.

31 March 2020

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p300 Transcriptional Repression Is Mediated by SUMO Modification

31 March 2020

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p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.

31 March 2020

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The multistage nature of chemically induced hepatocarcinogenesis in the rat.

31 March 2020

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Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester

31 March 2020

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Inhibition of apoptosis in human tumour cells by okadaic acid

31 March 2020

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Inhibition of radiation-induced apoptosis in vitro by tumor promoters

31 March 2020

1 reference

Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism

31 March 2020

1 reference

Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells

31 March 2020

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JNK targets p53 ubiquitination and degradation in nonstressed cells

31 March 2020

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Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth

31 March 2020

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A role for ATR in the DNA damage-induced phosphorylation of p53

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1455

1 reference

11 August 2017

1 reference

PubMed ID

15510160