(Q35976983)

11 August 2017

4 references

3 April 2019

20 June 2019

19 September 2019

14 September 2020

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours (English)

1 reference

biomedical investigative technique

11 August 2017

0 references

1 reference

19 September 2019

1 reference

14 September 2020

J M Brown

1

1 reference

PMCID

1968495

11 August 2017

language of work or name

English

0 references

publication date

1 June 1993

5 references

British Journal of Cancer

11 August 2017

3 April 2019

20 June 2019

19 September 2019

14 September 2020

5 references

11 August 2017

3 April 2019

20 June 2019

19 September 2019

14 September 2020

67

1 reference

11 August 2017

1163-1170

1 reference

11 August 2017

6

1 reference

https://scigraph.springernature.com/pub.10.1038/bjc.1993.220

11 August 2017

0 references

cites work

Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Hypoxia-mediated drugs for radiation and chemotherapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Modification of chemotherapy by nitroimidazoles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Tumor hypoxia: its impact on cancer therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Hypoxic cells as specific drug targets for chemotherapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Keynote address: hypoxic cell radiosensitizers: where next?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Hypoxic fractions of human tumors xenografted into mice: a review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Bioreductive drugs and the selective induction of tumour hypoxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Enhancement of alkylating agent activity by SR-4233 in the FSaIIC murine fibrosarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Definitive evidence for hypoxic cells influencing cure in cancer therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Therapeutic attack of hypoxic cells of solid tumors: presidential address

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Blood flow failure as a major determinant in the antitumor action of flavone acetic acid.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Pre- and post-irradiation radiosensitization by SR 4233.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Therapeutic advantage of hypoxic cells in tumors: a theoretical study

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1968495

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

24 September 2018

1 reference

12 December 2020

Toxicology of daily administration to mice of the radiation potentiator SR 4233 (WIN 59075)

1 reference

12 December 2020

Changes of Oxygen Tension in Tumours Induced by Vasoconstrictor and Vasodilator Drugs

1 reference

12 December 2020

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

1 reference

12 December 2020

Bioactivation as a model for drug design bioreductive alkylation

1 reference

12 December 2020

Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells

1 reference

12 December 2020

Combination therapy with radiation and mitomycin C: Preliminary results with EMT6 tumor cells in vitro and in vivo

1 reference

12 December 2020

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1 reference

12 December 2020

Mitomycin-C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity

1 reference

12 December 2020

Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole

1 reference

12 December 2020

A thin-film culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells

1 reference

12 December 2020

Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro

1 reference

12 December 2020

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions

1 reference

12 December 2020

Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant

1 reference

12 December 2020

Primary radiotherapy of larynx and pharynx carcinoma--an analysis of some factors influencing local control and survival

1 reference

12 December 2020

The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain

1 reference

12 December 2020

A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts

1 reference

12 December 2020

The relationship between radiation-induced DNA double-strand breaks and cell kill in hamster V79 fibroblasts irradiated with 250 kVp X-rays, 2.3 MeV neutrons or 238Pu alpha-particles

1 reference

12 December 2020

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

1 reference

12 December 2020

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1 reference

12 December 2020

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233

1 reference

12 December 2020

Breakage of human interphase chromosomes by alpha particles and X-rays

1 reference

12 December 2020

Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer

1 reference

12 December 2020

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

1 reference

12 December 2020

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively ac

1 reference

12 December 2020

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

1 reference

12 December 2020

SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes

1 reference

12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

1 reference

12 December 2020

Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical

1 reference

12 December 2020

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1993.220

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

1968495