(Q35986033)

11 August 2017

1 reference

title

Lessons from natural molecules (English)

1 reference

11 August 2017

2

Christopher Walsh

1 reference

11 August 2017

Jon Clardy

1

1 reference

PubMed ID

15602548

11 August 2017

language of work or name

English

0 references

publication date

1 December 2004

1 reference

11 August 2017

1 reference

11 August 2017

432

1 reference

11 August 2017

829-837

1 reference

11 August 2017

7019

1 reference

https://scigraph.springernature.com/pub.10.1038/nature03194

11 August 2017

0 references

cites work

The influence of natural products upon drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Natural products as sources of new drugs over the period 1981-2002.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Microtubule-stabilizing agents: a growing class of important anticancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

X-Ray crystal structure of staurosporine: a new alkaloid from a Streptomyces strain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Sildenafil: A 4-year update in the treatment of 20 million erectile dysfunction patients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

The discovery and development of atorvastatin, a potent novel hypolipidemic agent

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Structure of human methionine aminopeptidase-2 complexed with fumagillin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Hemiasterlin and geodiamolide TA; two new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Antibody-targeted chemotherapy with the calicheamicin conjugate hu3S193-N-acetyl gamma calicheamicin dimethyl hydrazide targets Lewisy and eliminates Lewisy-positive human carcinoma cells and xenografts

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Libraries from natural product-like scaffolds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Dysidiolide: A Novel Protein Phosphatase Inhibitor from the Caribbean SpongeDysidea etheriade Laubenfels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Target-oriented and diversity-oriented organic synthesis in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

A planning strategy for diversity-oriented synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Generating Diverse Skeletons of Small Molecules Combinatorially

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Vancomycin assembly: nature's way.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Nonribosomal peptides: from genes to products

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Enzyme Mechanisms for Polycyclic Triterpene Formation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Type I polyketide biosynthesis in bacteria (part B).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Enzymology of acyl chain macrocyclization in natural product biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

The calicheamicin gene cluster and its iterative type I enediyne PKS

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Taxol biosynthetic genes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Altering the glycosylation pattern of bioactive compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Nodulisporic acids C, C1, and C2: a series of D-ring-opened nodulisporic acids from the fungus Nodulisporium sp

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Metabolites from symbiotic bacteria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

A molecular view of microbial diversity and the biosphere

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Novel natural products from soil DNA libraries in a streptomycete host

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

New natural product families from an environmental DNA (eDNA) gene cluster

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03194

7 January 2021

Identifiers

DOI

10.1038/NATURE03194

1 reference

PubMed ID

15602548

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15602548