(Q36028155)

11 August 2017

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title

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling (English)

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11 August 2017

2

Jeffrey L Wrana

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11 August 2017

Christine Le Roy

1

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11 August 2017

1 February 2005

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Nature Reviews Molecular Cell Biology

11 August 2017

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11 August 2017

6

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11 August 2017

112-126

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11 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrm1571

11 August 2017

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31 March 2020

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

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Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

31 March 2020

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

31 March 2020

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ENTH/ANTH proteins and clathrin-mediated membrane budding

31 March 2020

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Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction

31 March 2020

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Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome

31 March 2020

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Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

31 March 2020

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

31 March 2020

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Hrs recruits clathrin to early endosomes

31 March 2020

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Vps27 recruits ESCRT machinery to endosomes during MVB sorting

31 March 2020

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Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

31 March 2020

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The biogenesis of multivesicular endosomes

31 March 2020

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Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

31 March 2020

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GM1-Containing Lipid Rafts Are Depleted within Clathrin-Coated Pits

31 March 2020

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Caveosomes and endocytosis of lipid rafts

31 March 2020

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Distribution and transport of cholesterol-rich membrane domains monitored by a membrane-impermeant fluorescent polyethylene glycol-derivatized cholesterol

31 March 2020

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Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol

31 March 2020

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Caveolae/raft-dependent endocytosis

31 March 2020

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Regulated internalization of caveolae

31 March 2020

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Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae

31 March 2020

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Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

31 March 2020

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Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic

31 March 2020

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Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

31 March 2020

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Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

31 March 2020

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31 March 2020

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Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway

31 March 2020

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GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.

31 March 2020

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Clathrin adaptors really adapt

31 March 2020

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

31 March 2020

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Regulated migration of epidermal growth factor receptor from caveolae

31 March 2020

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Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding

31 March 2020

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Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains

31 March 2020

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Second cysteine-rich region of epidermal growth factor receptor contains targeting information for caveolae/rafts

31 March 2020

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The caveolae membrane system

31 March 2020

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BAR domains as sensors of membrane curvature: the amphiphysin BAR structure

31 March 2020

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

31 March 2020

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EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

31 March 2020

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Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

31 March 2020

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Epidermal growth factor pathway substrate 15, Eps15.

31 March 2020

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Receptor downregulation and multivesicular-body sorting

31 March 2020

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Phosphorylation of Hrs downstream of the epidermal growth factor receptor

31 March 2020

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Signaling on the endocytic pathway

31 March 2020

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Untangling the ErbB signalling network

31 March 2020

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Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

31 March 2020

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Endocytosis and mitogenic signaling

31 March 2020

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Control of EGF receptor signaling by clathrin-mediated endocytosis.

31 March 2020

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Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

31 March 2020

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Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase

31 March 2020

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Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival

31 March 2020

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NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

31 March 2020

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Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

31 March 2020

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Mechanism of the spatio-temporal regulation of Ras and Rap1.

31 March 2020

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H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis

31 March 2020

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The EGF receptor: a nexus for trafficking and signaling

31 March 2020

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Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane

31 March 2020

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Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

31 March 2020

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Signaling pathways for PC12 cell differentiation: making the right connections

31 March 2020

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Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling

31 March 2020

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

31 March 2020

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.

31 March 2020

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APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

31 March 2020

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

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Mechanism of activation of the TGF-beta receptor

31 March 2020

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

31 March 2020

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

31 March 2020

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

31 March 2020

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Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface

31 March 2020

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Transforming growth factor beta receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptor

31 March 2020

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Differential requirement for type I and type II transforming growth factor beta receptor kinase activity in ligand-mediated receptor endocytosis

31 March 2020

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

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Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit

31 March 2020

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Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

31 March 2020

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TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2

31 March 2020

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Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11.

31 March 2020

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The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling

31 March 2020

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Early endosomal regulation of Smad-dependent signaling in endothelial cells

31 March 2020

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Cytoplasmic PML function in TGF-beta signalling

31 March 2020

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Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

31 March 2020

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Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

31 March 2020

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Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis

31 March 2020

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Caveolae: from cell biology to animal physiology

31 March 2020

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The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors

31 March 2020

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Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains

31 March 2020

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Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum

31 March 2020

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Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum

31 March 2020

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Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

31 March 2020

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A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex

31 March 2020

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Rapid cycling of lipid raft markers between the cell surface and Golgi complex

31 March 2020

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

31 March 2020

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Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

31 March 2020

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

31 March 2020

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

31 March 2020

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The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

31 March 2020

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Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

31 March 2020

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Regulated endocytic routing modulates wingless signaling in Drosophila embryos.

31 March 2020

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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

31 March 2020

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

31 March 2020

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Wnt proteins are lipid-modified and can act as stem cell growth factors

31 March 2020

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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

31 March 2020

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Subcellular targeting by membrane lipids

31 March 2020

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GPI-anchored proteins are organized in submicron domains at the cell surface.

31 March 2020

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Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

31 March 2020

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Lipid domain structure of the plasma membrane revealed by patching of membrane components

31 March 2020

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Resistance of cell membranes to different detergents

31 March 2020

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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

31 March 2020

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Lipid rafts: heterogeneity on the high seas

31 March 2020

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N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae

31 March 2020

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The sorbin homology domain: a motif for the targeting of proteins to lipid rafts

31 March 2020

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Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb

31 March 2020

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31 March 2020

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Coat proteins: shaping membrane transport

31 March 2020

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Maturation models for endosome and lysosome biogenesis

31 March 2020

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The arguments for pre-existing early and late endosomes

31 March 2020

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Dynamics of endosomal sorting

31 March 2020

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Caveolin, a protein component of caveolae membrane coats

31 March 2020

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Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

31 March 2020

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De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

31 March 2020

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Membrane microdomains and caveolae

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1571

1 reference

PubMed ID

15687999

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15687999