(Q36028214)

11 August 2017

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title

RNA polymerases I and III, growth control and cancer (English)

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11 August 2017

Robert J White

1

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11 August 2017

1 January 2005

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Nature Reviews Molecular Cell Biology

11 August 2017

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11 August 2017

6

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11 August 2017

69-78

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrm1551

11 August 2017

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ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

31 March 2020

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An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF

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The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB.

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The role of c-myc in cellular growth control

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Targeting RAS signalling pathways in cancer therapy

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MAPK-regulated transcription: a continuously variable gene switch?

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TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters

31 March 2020

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The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.

31 March 2020

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TATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells

31 March 2020

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Recruitment of human TBP selectively activates RNA polymerase II TATA-dependent promoters.

31 March 2020

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Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein

31 March 2020

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Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity

31 March 2020

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Ras enhances Myc protein stability.

31 March 2020

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

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Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

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Drosophila myc regulates cellular growth during development.

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Control of cell growth by c-Myc in the absence of cell division

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

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Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius

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Quantitative proteomic analysis of Myc oncoprotein function

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Genomic targets of the human c-Myc protein

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

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A role for c-Myc in the regulation of ribosomal RNA processing

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Direct activation of RNA polymerase III transcription by c-Myc

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MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Upstream and downstream of mTOR

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Modulation of transcription of rRNA genes by rapamycin

31 March 2020

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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

31 March 2020

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Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

31 March 2020

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Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes

31 March 2020

1 reference

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

31 March 2020

1 reference

Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.

31 March 2020

1 reference

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

31 March 2020

1 reference

PI 3-kinase, mTOR, protein synthesis and cancer

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

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Integration of Growth Factor and Nutrient Signaling

31 March 2020

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The TOR pathway: a target for cancer therapy

31 March 2020

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Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells

31 March 2020

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RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.

31 March 2020

1 reference

Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses

31 March 2020

1 reference

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

31 March 2020

1 reference

p53 is a general repressor of RNA polymerase III transcription

31 March 2020

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p53 represses ribosomal gene transcription

31 March 2020

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Repression of RNA polymerase I transcription by the tumor suppressor p53

31 March 2020

1 reference

p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.

31 March 2020

1 reference

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

31 March 2020

1 reference

Cancer. p53, guardian of the genome

31 March 2020

1 reference

31 March 2020

Surfing the p53 network

1 reference

Live or let die: the cell's response to p53

31 March 2020

1 reference

p53 mutations in human cancers

31 March 2020

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Several regions of p53 are involved in repression of RNA polymerase III transcription

31 March 2020

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RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome

31 March 2020

1 reference

Li-Fraumeni syndrome--a molecular and clinical review

31 March 2020

1 reference

The MDM2 gene amplification database

31 March 2020

1 reference

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

The RB and p53 pathways in cancer

31 March 2020

1 reference

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

31 March 2020

1 reference

Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis

31 March 2020

1 reference

Regulation of HDM2 activity by the ribosomal protein L11

31 March 2020

1 reference

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway

31 March 2020

1 reference

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

31 March 2020

1 reference

Cancer: guarding the guardian?

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

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Proliferation, cell cycle and apoptosis in cancer

31 March 2020

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Retinoblastoma protein partners

31 March 2020

1 reference

Regulation of cell proliferation by the E2F transcription factors

31 March 2020

1 reference

Sibling rivalry in the E2F family

31 March 2020

1 reference

Coordination of growth and cell division in the Drosophila wing.

31 March 2020

1 reference

The retinoblastoma protein and cell cycle control

31 March 2020

1 reference

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

31 March 2020

1 reference

The retinoblastoma gene family: cousins with overlapping interests.

31 March 2020

1 reference

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

31 March 2020

1 reference

Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket

31 March 2020

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Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

31 March 2020

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Repression of RNA polymerase III transcription by the retinoblastoma protein

31 March 2020

1 reference

RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2

31 March 2020

1 reference

Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein

31 March 2020

1 reference

Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein

31 March 2020

1 reference

Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription

31 March 2020

1 reference

Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein

31 March 2020

1 reference

Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription

31 March 2020

1 reference

Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1

31 March 2020

1 reference

RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

31 March 2020

1 reference

Regulation of RNA polymerase III transcription during cell cycle entry

31 March 2020

1 reference

RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130.

31 March 2020

1 reference

Overlapping functions of the pRb family in the regulation of rRNA synthesis

31 March 2020

1 reference

Survey and summary: transcription by RNA polymerases I and III.

31 March 2020

1 reference

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

31 March 2020

1 reference

Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening

31 March 2020

1 reference

Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer.

31 March 2020

1 reference

Identification of a growth suppression domain within the retinoblastoma gene product

31 March 2020

1 reference

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding

31 March 2020

1 reference

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

31 March 2020

1 reference

Cyclin D1 as a cellular proto-oncogene.

31 March 2020

1 reference

p16(MTS-1/CDKN2/INK4a) in cancer progression

31 March 2020

1 reference

Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.

31 March 2020

1 reference

Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription

31 March 2020

1 reference

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

31 March 2020

1 reference

Papillomaviruses and cancer: from basic studies to clinical application

31 March 2020

1 reference

Activation of RNA polymerase III transcription in cells transformed by simian virus 40

31 March 2020

1 reference

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

31 March 2020

1 reference

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

31 March 2020

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

31 March 2020

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Cellular targets for transformation by the adenovirus E1A proteins

31 March 2020

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The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression

31 March 2020

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The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells

31 March 2020

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The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells

31 March 2020

1 reference

Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus

31 March 2020

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Recruitment of RNA polymerase III to its target promoters

31 March 2020

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Integration of growth factor and nutrient signaling: implications for cancer biology

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1551

1 reference

11 August 2017

1 reference

PubMed ID

15688068