(Q36062695)

11 August 2017

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title

Cell culture-based models for intestinal permeability: a critique (English)

1 reference

11 August 2017

Praveen V Balimane

1

1 reference

PubMed ID

15749282

11 August 2017

Saeho Chong

series ordinal

2

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11 August 2017

1 March 2005

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11 August 2017

1 reference

11 August 2017

10

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11 August 2017

335-343

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11 August 2017

5

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Predicting oral absorption and bioavailability

11 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Comparison of in vitro models for the prediction of compound absorption across the human intestinal mucosa

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Current methodologies used for evaluation of intestinal permeability and absorption

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Physicochemical profiling (solubility, permeability and charge state).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Assessing the absorption of new pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

High throughput physicochemical profiling for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Transcellular uptake mechanisms of the intestinal epithelial barrier Part one.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Characterization of the transport of uracil across Caco-2 and LLC-PK1 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Passive transepithelial absorption of thyrotropin-releasing hormone (TRH) via a paracellular route in cultured intestinal and renal epithelial cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Cell cultures as tools in biopharmacy.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Evaluation of Biocoat intestinal epithelium differentiation environment (3-day cultured Caco-2 cells) as an absorption screening model with improved productivity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Regulation of the intestinal epithelial paracellular barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Enhancing paracellular permeability by modulating epithelial tight junctions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Permeability of lipophilic compounds in drug discovery using in-vitro human absorption model, Caco-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Effect of bovine serum albumin on drug permeability estimation across Caco-2 monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Gastrointestinal parameters that influence oral medications

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

HPLC with programmed wavelength fluorescence detection for the simultaneous determination of marker compounds of integrity and P-gp functionality in the Caco-2 intestinal absorption model

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Effect of common excipients on Caco-2 transport of low-permeability drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

P-glycoprotein attenuating effect of human intestinal fluid.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Simulated intestinal fluid as transport medium in the Caco-2 cell culture model.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

New and better protocols for a short-term Caco-2 cell culture system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Evaluation of an accelerated Caco-2 cell permeability model.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903354-9

7 January 2021

10.1016/S1359-6446(04)03354-9

Identifiers

DOI

1 reference

11 August 2017

1 reference

PubMed ID

15749282