(Q36068780)

12 August 2017

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title

Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? (English)

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12 August 2017

P Lenert

1

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12 August 2017

1 April 2005

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Clinical and Experimental Immunology

12 August 2017

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12 August 2017

140

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12 August 2017

1-10

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12 August 2017

1

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Innate immune recognition

12 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Dendritic cells and the control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Human peripheral blood contains two distinct lineages of dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

The nature of the principal type 1 interferon-producing cells in human blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

The central role of dendritic cells and interferon-alpha in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Liver-derived DEC205+B220+CD19- dendritic cells regulate T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Regulatory role of mature B cells in a murine model of inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

B cells regulate autoimmunity by provision of IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Prevention of arthritis by interleukin 10-producing B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Autoreactivity by design: innate B and T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

21 January 2018

Marginal-zone B cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Autoreactive B cells in the marginal zone that express dual receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Rapid response of marginal zone B cells to viral particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Integrin-mediated long-term B cell retention in the splenic marginal zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Separation of the New Zealand Black genetic contribution to lupus from New Zealand Black determined expansions of marginal zone B and B1a cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Differential signaling by CpG DNA in DCs and B cells: not just TLR9

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Innate immune responses in lupus-prone Palmerston North mice: differential responses to LPS and bacterial DNA/CpG oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Autoimmunity through cytokine-induced dendritic cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Systemic exposure to irradiated apoptotic cells induces autoantibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Infections in outpatients with systemic lupus erythematosus: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Direct immunologic activities of CpG DNA and implications for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

Bacterial DNA causes septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02728.X

B cells turn off virgin but not memory T cells

21 January 2018

1 reference

12 December 2020

The origin, sequence, structure, and consequences of developing anti-DNA antibodies. A human perspective

1 reference

12 December 2020

Role of T cell DNA methylation in lupus syndromes

1 reference

12 December 2020

In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers

1 reference

12 December 2020

Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.

1 reference

12 December 2020

Effect of Suppressive DNA on CpG-Induced Immune Activation

1 reference

12 December 2020

Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice

1 reference

12 December 2020

Does activation of the innate immune system contribute to the development of rheumatoid arthritis?

1 reference

12 December 2020

Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells

1 reference

12 December 2020

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus

1 reference

12 December 2020

Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB x NZW)F(1) mice

1 reference

12 December 2020

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

1 reference

12 December 2020

T cell-independent antigens type 2.

1 reference

12 December 2020

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo

1 reference

12 December 2020

CpG DNA: a pathogenic factor in systemic lupus erythematosus?

1 reference

12 December 2020

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

1 reference

12 December 2020

Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides.

1 reference

12 December 2020

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA

1 reference

12 December 2020

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

1 reference

12 December 2020

B lymphocytes as autoantigen-presenting cells in the amplification of autoimmunity

1 reference

12 December 2020

A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice.

1 reference

12 December 2020

CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry.

1 reference

12 December 2020

B lymphocytes as antigen-presenting cells for CD4+ T cell priming in vivo

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12 December 2020

Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis

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12 December 2020

Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells

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12 December 2020

Activation of autoreactive B cells by CpG dsDNA

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12 December 2020

Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors

1 reference

12 December 2020

Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides

1 reference

12 December 2020

TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production.

1 reference

12 December 2020

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature

1 reference

12 December 2020

Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

1 reference

12 December 2020

Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice

1 reference

12 December 2020

Type I IFN protects against murine lupus

1 reference

12 December 2020

IL-10-producing B220+CD11c- APC in mouse spleen

1 reference

12 December 2020

Studies on the capacity of B cells to serve as antigen-presenting cells

1 reference

12 December 2020

Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content

1 reference

12 December 2020

Serum interferon levels in patients with systemic lupus erythematosus

1 reference

12 December 2020

Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model

1 reference

12 December 2020

Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA

1 reference

12 December 2020

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis

1 reference

12 December 2020

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

1 reference

12 December 2020

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity

1 reference

12 December 2020

10.1111/J.1365-2249.2004.02728.X

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15762869