(Q36085605)

12 August 2017

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title

The cornified envelope: a model of cell death in the skin. (English)

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Gene Ontology release 2020-05-02

12 August 2017

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Eleonora Candi

1

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PubMed ID

15803139

12 August 2017

Rainer Schmidt

series ordinal

2

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PubMed ID

15803139

12 August 2017

Gerry Melino

series ordinal

3

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12 August 2017

1 April 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

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12 August 2017

6

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12 August 2017

328-340

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12 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrm1619

12 August 2017

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cites work

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

1 reference

Morphological and biochemical characterization of the cornified envelopes from human epidermal keratinocytes of different origin

31 March 2020

1 reference

Epithelial barrier function: assembly and structural features of the cornified cell envelope

31 March 2020

1 reference

A structural scaffolding of intermediate filaments in health and disease

31 March 2020

1 reference

Molecular architecture of intermediate filaments

31 March 2020

1 reference

Phenotypes, genotypes and their contribution to understanding keratin function

31 March 2020

1 reference

Identification of Late Differentiation Antigens of Human Cornified Epithelia, Expressed in Re-Organized Desmosomes and Bound to Cross-Linked Envelope

31 March 2020

1 reference

Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes.

31 March 2020

1 reference

Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function

31 March 2020

1 reference

Transglutaminases: crosslinking enzymes with pleiotropic functions

31 March 2020

1 reference

Targeted ablation of the murine involucrin gene

31 March 2020

1 reference

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

31 March 2020

1 reference

A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases

31 March 2020

1 reference

A mutation in the V1 end domain of keratin 1 in non-epidermolytic palmar-plantar keratoderma

31 March 2020

1 reference

S100 protein subcellular localization during epidermal differentiation and psoriasis

31 March 2020

1 reference

S100A7, S100A10, and S100A11 are transglutaminase substrates

31 March 2020

1 reference

S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes

31 March 2020

1 reference

Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21

31 March 2020

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Differentially expressed late constituents of the epidermal cornified envelope

31 March 2020

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The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein

31 March 2020

1 reference

Structure and evolution of the human involucrin gene

31 March 2020

1 reference

A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation

31 March 2020

1 reference

Glycine loops in proteins: their occurence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins

31 March 2020

1 reference

S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes

31 March 2020

1 reference

Structure, function, and dynamics of keratin intermediate filaments

31 March 2020

1 reference

Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein

31 March 2020

1 reference

Overexpression of human loricrin in transgenic mice produces a normal phenotype

31 March 2020

1 reference

Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes

31 March 2020

1 reference

Phosphorylated cystatin alpha is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope

31 March 2020

1 reference

Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin

31 March 2020

1 reference

Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins

31 March 2020

1 reference

Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein

31 March 2020

1 reference

Small proline-rich proteins are cross-bridging proteins in the cornified cell envelopes of stratified squamous epithelia

31 March 2020

1 reference

Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21

31 March 2020

1 reference

Organization, structure, and polymorphisms of the human profilaggrin gene

31 March 2020

1 reference

Multiple copies of phosphorylated filaggrin in epidermal profilaggrin demonstrated by analysis of tryptic peptides

31 March 2020

1 reference

Characterization of protease processing sites during conversion of rat profilaggrin to filaggrin

31 March 2020

1 reference

Characterization of a class of cationic proteins that specifically interact with intermediate filaments

31 March 2020

1 reference

The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis

31 March 2020

1 reference

Profilaggrin is a major epidermal calcium-binding protein

31 March 2020

1 reference

Role of integrins in regulating epidermal adhesion, growth and differentiation

31 March 2020

1 reference

Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation

31 March 2020

1 reference

Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation

31 March 2020

1 reference

Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?

31 March 2020

1 reference

Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes

31 March 2020

1 reference

Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation

31 March 2020

1 reference

Autoimmunity against desmosomal cadherins in pemphigus

31 March 2020

1 reference

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma

31 March 2020

1 reference

Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome

31 March 2020

1 reference

Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease

31 March 2020

1 reference

Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

31 March 2020

1 reference

Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1

31 March 2020

1 reference

Structure and organization of the human transglutaminase 3 gene: evolutionary relationship to the transglutaminase family

31 March 2020

1 reference

Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation

31 March 2020

1 reference

Transglutaminase 1 Mutations in Lamellar Ichthyosis

31 March 2020

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Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.

31 March 2020

1 reference

Cathepsin S activity is detectable in human keratinocytes and is selectively upregulated upon stimulation with interferon-gamma.

31 March 2020

1 reference

Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2.

31 March 2020

1 reference

Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation

31 March 2020

1 reference

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling

31 March 2020

1 reference

Biochemical demonstration and immunohistochemical localization of calpain in human skin.

31 March 2020

1 reference

Cytoplasmic processing of human profilaggrin by active mu-calpain

31 March 2020

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The calpain small subunit gene is essential: its inactivation results in embryonic lethality.

31 March 2020

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Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

31 March 2020

1 reference

Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies

31 March 2020

1 reference

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

31 March 2020

1 reference

Structure of the skin barrier and its modulation by vesicular formulations

31 March 2020

1 reference

Barrier function of the skin: "la raison d'être" of the epidermis

31 March 2020

1 reference

Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis

31 March 2020

1 reference

The epidermal permeability barrier

31 March 2020

1 reference

Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization.

31 March 2020

1 reference

Lamellar body secretory response to barrier disruption

31 March 2020

1 reference

Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease

31 March 2020

1 reference

Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier

31 March 2020

1 reference

Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis

31 March 2020

1 reference

Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy

31 March 2020

1 reference

Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

31 March 2020

1 reference

Role for ELOVL3 and fatty acid chain length in development of hair and skin function

31 March 2020

1 reference

The permeability barrier in mammalian epidermis

31 March 2020

1 reference

Mammalian epidermal barrier layer lipids: composition and influence on structure

31 March 2020

1 reference

Skin barrier formation: the membrane folding model

31 March 2020

1 reference

Ceramides and the stratum corneum: structure, function, and new methods to promote repair

31 March 2020

1 reference

New acylceramide in native and reconstructed epidermis

31 March 2020

1 reference

Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope

31 March 2020

1 reference

Mutations of keratinocyte transglutaminase in lamellar ichthyosis

31 March 2020

1 reference

Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis

31 March 2020

1 reference

Two new loci for autosomal recessive ichthyosis on chromosomes 3p21 and 19p12-q12 and evidence for further genetic heterogeneity

31 March 2020

1 reference

Identification, by homozygosity mapping, of a novel locus for autosomal recessive congenital ichthyosis on chromosome 17p, and evidence for further genetic heterogeneity.

31 March 2020

1 reference

Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2

31 March 2020

1 reference

Mapping of a second locus for lamellar ichthyosis to chromosome 2q33-35.

31 March 2020

1 reference

A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome

31 March 2020

1 reference

The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope

31 March 2020

1 reference

Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system

31 March 2020

1 reference

Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma

31 March 2020

1 reference

Intermediate filaments: conformity and diversity of expression and structure

31 March 2020

1 reference

Molecular and cellular biology of intermediate filaments

31 March 2020

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Intermediate filament dynamics

31 March 2020

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Enzymatic basis of typical X-linked icthyosis

31 March 2020

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Cholesterol 3-sulfate interferes with cornified envelope assembly by diverting transglutaminase 1 activity from the formation of cross-links and esters to the hydrolysis of glutamine

31 March 2020

1 reference

Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

31 March 2020

1 reference

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

31 March 2020

1 reference

Gaucher disease in the neonate: a distinct Gaucher phenotype is analogous to a mouse model created by targeted disruption of the glucocerebrosidase gene

31 March 2020

1 reference

Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome

31 March 2020

1 reference

Truncation of CGI-58 protein causes malformation of lamellar granules resulting in ichthyosis in Dorfman-Chanarin syndrome.

31 March 2020

1 reference

Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome

31 March 2020

1 reference

Inactive zymogen and highly active proteolytically processed membrane-bound forms of the transglutaminase 1 enzyme in human epidermal keratinocytes

31 March 2020

1 reference

Highly active soluble processed forms of the transglutaminase 1 enzyme in epidermal keratinocytes

31 March 2020

1 reference

Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells

31 March 2020

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Gene disruption of tissue transglutaminase

31 March 2020

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Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb.

31 March 2020

1 reference

The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases

31 March 2020

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Expression of transglutaminase 5 in normal and pathologic human epidermis

31 March 2020

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Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro

31 March 2020

1 reference

A novel superfamily of enzymes that catalyze the modification of guanidino groups.

31 March 2020

1 reference

Decreased deiminated keratin K1 in psoriatic hyperproliferative epidermis

31 March 2020

1 reference

Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin

31 March 2020

1 reference

Identification of citrulline residues in the V subdomains of keratin K1 derived from the cornified layer of newborn mouse epidermis

31 March 2020

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Sequential reorganization of cornified cell keratin filaments involving filaggrin-mediated compaction and keratin 1 deimination

31 March 2020

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Changing Pattern of Deiminated Proteins in Developing Human Epidermis

31 March 2020

1 reference

Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin

31 March 2020

1 reference

Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene

31 March 2020

1 reference

Identification of PEX7 as the second gene involved in Refsum disease

31 March 2020

1 reference

Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hünermann syndrome

31 March 2020

1 reference

CHILD syndrome caused by deficiency of 3beta-hydroxysteroid-delta8, delta7-isomerase

31 March 2020

1 reference

Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome

31 March 2020

1 reference

Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1619

1 reference

12 August 2017

1 reference

PubMed ID

15803139