(Q36085684)

12 August 2017

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title

Strategies for mapping and cloning quantitative trait genes in rodents (English)

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12 August 2017

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Sagiv Shifman

3

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Jonathan Flint

object named as

Jonathan Flint

series ordinal

1

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author name string

William Valdar

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2

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12 August 2017

Richard Mott

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4

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12 August 2017

publication date

1 April 2005

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12 August 2017

published in

Nature Reviews Genetics

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12 August 2017

volume

6

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12 August 2017

issue

4

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12 August 2017

page(s)

271-286

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Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

12 August 2017

cites work

1 reference

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat

31 March 2020

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Genetic analysis of autoimmune type 1 diabetes mellitus in mice

31 March 2020

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QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice.

31 March 2020

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QTL analysis of multiple behavioral measures of anxiety in mice

31 March 2020

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The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies.

31 March 2020

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The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

31 March 2020

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From QTL to gene: the harvest begins

31 March 2020

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Finding genes that underlie complex traits

31 March 2020

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"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.

31 March 2020

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Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene

31 March 2020

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Mpdz is a quantitative trait gene for drug withdrawal seizures.

31 March 2020

1 reference

Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping

31 March 2020

1 reference

Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL

31 March 2020

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Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains

31 March 2020

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Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL.

31 March 2020

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Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats

31 March 2020

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Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats

31 March 2020

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Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1

31 March 2020

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Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

31 March 2020

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Identification of two quantitative trait loci involved in antibody production on mouse chromosome 8

31 March 2020

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The genetic architecture of quantitative traits

31 March 2020

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Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.

31 March 2020

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The genetic architecture of quantitative traits: lessons from Drosophila

31 March 2020

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Dissecting the architecture of a quantitative trait locus in yeast

31 March 2020

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Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats

31 March 2020

1 reference

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.

31 March 2020

1 reference

Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects.

31 March 2020

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Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice

31 March 2020

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Scanning Human Gene Deserts for Long-Range Enhancers

31 March 2020

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Accuracy of mapping quantitative trait loci in autogamous species

31 March 2020

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A simple method to calculate resolving power and confidence interval of QTL map location

31 March 2020

1 reference

Experimental strategies for the genetic dissection of complex traits in animal models

31 March 2020

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Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain

31 March 2020

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Analysing complex genetic traits with chromosome substitution strains

31 March 2020

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Consomic rat model systems for physiological genomics

31 March 2020

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Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice

31 March 2020

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Genetic dissection of complex traits with chromosome substitution strains of mice.

31 March 2020

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Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping

31 March 2020

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The Collaborative Cross, a community resource for the genetic analysis of complex traits

31 March 2020

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Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains

31 March 2020

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Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice

31 March 2020

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Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis

31 March 2020

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A new set of BXD recombinant inbred lines from advanced intercross populations in mice

31 March 2020

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Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping

31 March 2020

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Speed congenics: accelerated genome recovery using genetic markers

31 March 2020

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Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

31 March 2020

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The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer

31 March 2020

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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes

31 March 2020

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Genetic variation in DLG5 is associated with inflammatory bowel disease

31 March 2020

1 reference

The gene encoding phosphodiesterase 4D confers risk of ischemic stroke

31 March 2020

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A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

31 March 2020

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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

31 March 2020

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

31 March 2020

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Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation.

31 March 2020

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Fine scale mapping of a genetic locus for conditioned fear.

31 March 2020

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A method for fine mapping quantitative trait loci in outbred animal stocks

31 March 2020

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High-resolution mapping of quantitative trait loci in outbred mice

31 March 2020

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Distinct genetic loci control development of benign and malignant skin tumours in mice

31 March 2020

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A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

31 March 2020

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

31 March 2020

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Outbred CD-1 mice carry the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1) locus

31 March 2020

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The future of association studies: gene-based analysis and replication

31 March 2020

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The complex interplay among factors that influence allelic association.

31 March 2020

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Prospects for admixture mapping of complex traits

31 March 2020

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Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping

31 March 2020

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Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity

31 March 2020

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Haplotype analysis in multiple crosses to identify a QTL gene

31 March 2020

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Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.

31 March 2020

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Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes

31 March 2020

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A collaborative database of inbred mouse strain characteristics.

31 March 2020

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In silico mapping of complex disease-related traits in mice.

31 March 2020

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Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female

31 March 2020

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Genealogies of mouse inbred strains

31 March 2020

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The mosaic structure of variation in the laboratory mouse genome

31 March 2020

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Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse

31 March 2020

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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

31 March 2020

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In silico genetics: identification of a functional element regulating H2-Ealpha gene expression

31 March 2020

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Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse

31 March 2020

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Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice.

31 March 2020

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Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome

31 March 2020

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Genetic and haplotype diversity among wild-derived mouse inbred strains.

31 March 2020

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Regional and strain-specific gene expression mapping in the adult mouse brain

31 March 2020

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Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

31 March 2020

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Regulation of bone mass in mice by the lipoxygenase gene Alox15

31 March 2020

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Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus

31 March 2020

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Microarray analysis of rat chromosome 2 congenic strains

31 March 2020

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Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

31 March 2020

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Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes

31 March 2020

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Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes

31 March 2020

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Dissecting complex traits: the geneticists' "Around the world in 80 days".

31 March 2020

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A gene-driven approach to the identification of ENU mutants in the mouse

31 March 2020

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Analysis of quantitative trait loci that influence animal behavior

31 March 2020

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Pyruvate kinase deficiency in mice protects against malaria

31 March 2020

1 reference

Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs

31 March 2020

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Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

31 March 2020

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Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

31 March 2020

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Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg

31 March 2020

1 reference

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

1 reference

The genetics of complex autoimmune diseases: non-MHC susceptibility genes

31 March 2020

1 reference

An epistatic genetic basis for fluctuating asymmetry of mandible size in mice

31 March 2020

1 reference

Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse

31 March 2020

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Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice.

31 March 2020

1 reference

A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice

31 March 2020

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A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

31 March 2020

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Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

31 March 2020

1 reference

The knockout mouse project

31 March 2020

1 reference

Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains

31 March 2020

1 reference

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

31 March 2020

1 reference

Mapping of quantitative trait loci with knockout/congenic strains

31 March 2020

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The recombinant congenic strains—a novel genetic tool applied to the study of colon tumor development in the mouse

31 March 2020

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Genome-tagged mice (GTM): two sets of genome-wide congenic strains

31 March 2020

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Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity

31 March 2020

1 reference

A large-sample QTL study in mice: I. Growth

31 March 2020

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A large-sample QTL study in mice: II. Body composition

31 March 2020

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QTLs for pre- and postweaning body weight and body composition in selected mice

31 March 2020

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Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice

31 March 2020

1 reference

Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains

31 March 2020

1 reference

Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice

31 March 2020

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Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.

31 March 2020

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Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice

31 March 2020

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Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice

31 March 2020

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Mapping quantitative trait loci for murine growth: a closer look at genetic architecture

31 March 2020

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Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice

31 March 2020

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Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains

31 March 2020

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Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

31 March 2020

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High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains

31 March 2020

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Reciprocal hemizygosity analysis of mouse hepatic lipase reveals influence on obesity

31 March 2020

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Angiotensin-converting enzyme 2 is an essential regulator of heart function

31 March 2020

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Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

31 March 2020

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Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

31 March 2020

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Positional cloning of the mouse saccharin preference (Sac) locus

31 March 2020

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Functional alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses

31 March 2020

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Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

31 March 2020

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Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

31 March 2020

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Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).

31 March 2020

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Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

31 March 2020

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

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DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

31 March 2020

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Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

31 March 2020

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Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1576

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12 August 2017

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