(Q36090988)

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6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists

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Europe PubMed Central

PMC publication ID

12 August 2017

6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

Edward J Bilsky

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Edward J Bilsky

5

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Hamid I. Akbarali

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Hamid I Akbarali

6

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author name string

Yunyun Yuan

1

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Europe PubMed Central

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12 August 2017

David L Stevens

2

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Europe PubMed Central

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12 August 2017

Amanda Braithwaite

3

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Europe PubMed Central

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12 August 2017

Krista L Scoggins

4

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Europe PubMed Central

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12 August 2017

William L Dewey

7

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Europe PubMed Central

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12 August 2017

Yan Zhang

8

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12 August 2017

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publication date

26 May 2012

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12 August 2017

Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

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12 August 2017

22

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Europe PubMed Central

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12 August 2017

14

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Europe PubMed Central

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12 August 2017

4731-4734

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Preclinical disposition (in vitro) of novel μ-opioid receptor selective antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Morphine tolerance in the mouse ileum and colon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Methylnaltrexone for opioid-induced constipation in advanced illness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Opioids and the gut: pharmacology and current clinical experience.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Insights into opioid action in the intestinal tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Endogenous opioid peptides: multiple agonists and receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

2 October 2017

Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

Effects of fasting on evaluation of gastrointestinal transit with charcoal meal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

Effects of lactulose and polyethylene glycol on colonic transit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3395321

23 September 2018

Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683223

12 December 2020

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Identifiers

10.1016/J.BMCL.2012.05.075

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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