(Q36093125)

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

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scholarly article

1 reference

Europe PubMed Central

12 August 2017

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (English)

1 reference

Europe PubMed Central

12 August 2017

0 references

Magnus Ingelman-Sundberg

12

object named as

Magnus Ingelman-Sundberg

0 references

Lysiane Richert

6

object named as

Lysiane Richert

1 reference

Europe PubMed Central

12 August 2017

author name string

Rowena L C Sison-Young

1

1 reference

Europe PubMed Central

12 August 2017

Dimitra Mitsa

2

1 reference

Europe PubMed Central

12 August 2017

Rosalind E Jenkins

3

1 reference

Europe PubMed Central

12 August 2017

David Mottram

4

1 reference

Europe PubMed Central

12 August 2017

Eliane Alexandre

5

1 reference

Europe PubMed Central

12 August 2017

Hélène Aerts

7

1 reference

Europe PubMed Central

12 August 2017

Richard J Weaver

8

1 reference

Europe PubMed Central

12 August 2017

Robert P Jones

9

1 reference

Europe PubMed Central

12 August 2017

Esther Johann

10

1 reference

Europe PubMed Central

12 August 2017

Philip G Hewitt

11

1 reference

Europe PubMed Central

12 August 2017

Christopher E P Goldring

13

1 reference

Europe PubMed Central

12 August 2017

Neil R Kitteringham

14

1 reference

Europe PubMed Central

12 August 2017

B Kevin Park

15

1 reference

Europe PubMed Central

12 August 2017

publication date

8 July 2015

1 reference

Europe PubMed Central

12 August 2017

Toxicological Sciences

1 reference

Europe PubMed Central

12 August 2017

147

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Europe PubMed Central

12 August 2017

412-424

1 reference

Europe PubMed Central

12 August 2017

2

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Europe PubMed Central

12 August 2017

describes a project that uses

0 references

0 references

3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells

1 reference

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2 October 2017

Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters

1 reference

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2 October 2017

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.

1 reference

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Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications

1 reference

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2 October 2017

In vitro platforms for evaluating liver toxicity

1 reference

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2 October 2017

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

1 reference

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2 October 2017

Toward predictive models for drug-induced liver injury in humans: are we there yet?

1 reference

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Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities

1 reference

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2 October 2017

Oncogenic functions of the transcription factor Nrf2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Emerging transporters of clinical importance: an update from the International Transporter Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Global quantification of mammalian gene expression control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Perfused multiwell plate for 3D liver tissue engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

1 reference

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583060

2 October 2017

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

1 reference

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Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

1 reference

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Origin and characterization of a human bipotent liver progenitor cell line

1 reference

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Infection of a human hepatoma cell line by hepatitis B virus

1 reference

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Concordance of the toxicity of pharmaceuticals in humans and in animals

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays

1 reference

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2 July 2018

Hepatocyte cryopreservation: is it time to change the strategy?

1 reference

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2 July 2018

Hexokinase binding to mitochondria: a basis for proliferative energy metabolism

1 reference

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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.

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1 reference

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1 reference

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1 reference

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based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/26160117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/TOXSCI/KFV136

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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