(Q36111918)

12 August 2017

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title

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors (English)

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12 August 2017

Prakash Jagtap

1

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PubMed ID

15864271

12 August 2017

Csaba Szabó

series ordinal

2

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12 August 2017

1 May 2005

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Nature Reviews Drug Discovery

12 August 2017

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12 August 2017

4

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12 August 2017

421-440

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12 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd1718

12 August 2017

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cites work

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

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21 January 2018

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The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

21 January 2018

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Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.

21 January 2018

1 reference

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.

21 January 2018

1 reference

The interaction of adenosine diphosphoribosyl transferase (ADPRT) with a cruciform DNA.

21 January 2018

1 reference

PARP-1, a determinant of cell survival in response to DNA damage

21 January 2018

1 reference

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

21 January 2018

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Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein

21 January 2018

1 reference

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

21 January 2018

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Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction.

21 January 2018

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Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

21 January 2018

1 reference

Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice

21 January 2018

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Poly(ADP‐ribose) and carcinogenesis

21 January 2018

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Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice

21 January 2018

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Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

21 January 2018

1 reference

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy

21 January 2018

1 reference

21 January 2018

PARP goes transcription

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Modulation of DNMT1 activity by ADP-ribose polymers

21 January 2018

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The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders

21 January 2018

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Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.

21 January 2018

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Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.

21 January 2018

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Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

21 January 2018

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Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells

21 January 2018

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Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis

21 January 2018

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Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.

21 January 2018

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Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice

21 January 2018

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Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia

21 January 2018

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Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia

21 January 2018

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Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

21 January 2018

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Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans

21 January 2018

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Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

21 January 2018

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Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.

21 January 2018

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Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

21 January 2018

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

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DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite

21 January 2018

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Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

21 January 2018

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NAD and poly(ADP-ribose) regulation of proteins involved in response to cellular stress and DNA damage

21 January 2018

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NAD+ as a metabolic link between DNA damage and cell death.

21 January 2018

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Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited

21 January 2018

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NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes

21 January 2018

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Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.

21 January 2018

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Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor

21 January 2018

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Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

21 January 2018

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Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

21 January 2018

1 reference

Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock

21 January 2018

1 reference

Mitochondrial poly(ADP-ribosylation): from old data to new perspectives.

21 January 2018

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Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase

21 January 2018

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Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells

21 January 2018

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Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion.

21 January 2018

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Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences

21 January 2018

1 reference

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

21 January 2018

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Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery

21 January 2018

1 reference

Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase

21 January 2018

1 reference

Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

21 January 2018

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Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.

21 January 2018

1 reference

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

21 January 2018

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Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing

21 January 2018

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Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure

21 January 2018

1 reference

Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure

21 January 2018

1 reference

Poly(ADP-ribose) polymerase-1 and ionizing radiation: sensor, signaller and therapeutic target

21 January 2018

1 reference

4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer

21 January 2018

1 reference

Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase.

21 January 2018

1 reference

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

21 January 2018

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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling

21 January 2018

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The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

21 January 2018

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Pharmacological Modulation of Poly(ADP-ribose) Polymerase-Mediated Cell Death: Exploitation in Cancer Chemotherapy

21 January 2018

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Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

21 January 2018

1 reference

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase

21 January 2018

1 reference

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase

21 January 2018

1 reference

Inhibitors and activators of ADP-ribosylation reactions

21 January 2018

1 reference

Poly(ADP-ribose) polymerase inhibitors

21 January 2018

1 reference

Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

21 January 2018

1 reference

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

21 January 2018

1 reference

Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats.

21 January 2018

1 reference

GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation.

21 January 2018

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GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat

21 January 2018

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Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor

21 January 2018

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Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure

21 January 2018

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Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation

21 January 2018

1 reference

A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia

21 January 2018

1 reference

A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice

21 January 2018

1 reference

Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage

21 January 2018

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Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.

21 January 2018

1 reference

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia

21 January 2018

1 reference

Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.

21 January 2018

1 reference

Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.

21 January 2018

1 reference

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

21 January 2018

1 reference

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

21 January 2018

1 reference

Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury

21 January 2018

1 reference

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.

21 January 2018

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Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure

31 March 2020

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Inhibition of DNA binding by the phosphorylation of poly ADP-ribose polymerase protein catalysed by protein kinase C

31 March 2020

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PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development

31 March 2020

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ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

31 March 2020

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Down-regulation of DNA repair synthesis at DNA single-strand interruptions in poly(ADP-ribose) polymerase-1 deficient murine cell extracts

31 March 2020

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Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.

31 March 2020

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Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia

31 March 2020

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Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation.

31 March 2020

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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

31 March 2020

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Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells

31 March 2020

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Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.

31 March 2020

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Modulation of poly(ADP-ribosylation) in apoptotic cells

31 March 2020

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Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro

31 March 2020

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Apoptosis in the absence of poly-(ADP-ribose) polymerase

31 March 2020

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Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation

31 March 2020

1 reference

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

31 March 2020

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Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection

31 March 2020

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Poly(ADP-ribose) polymerase activation in the reperfused myocardium

31 March 2020

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Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes.

31 March 2020

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Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

31 March 2020

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Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion

31 March 2020

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Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase

31 March 2020

1 reference

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis

31 March 2020

1 reference

Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes

31 March 2020

1 reference

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite

31 March 2020

1 reference

Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation

31 March 2020

1 reference

Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy

31 March 2020

1 reference

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

31 March 2020

1 reference

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

31 March 2020

1 reference

PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.

31 March 2020

1 reference

Trans-dominant inhibition of poly(ADP-ribosyl)ation leads to decreased recovery from ionizing radiation-induced cell killing

31 March 2020

1 reference

Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine

31 March 2020

1 reference

Beneficial effects of GPI 6150, an inhibitor of poly(ADP-ribose) polymerase in a rat model of splanchnic artery occlusion and reperfusion

31 March 2020

1 reference

Drug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5'-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups

31 March 2020

1 reference

Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents

31 March 2020

1 reference

Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation

31 March 2020

1 reference

Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis

31 March 2020

1 reference

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase

31 March 2020

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The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes

31 March 2020

1 reference

Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

31 March 2020

1 reference

A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats

31 March 2020

1 reference

Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones

31 March 2020

1 reference

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

31 March 2020

1 reference

Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries.

31 March 2020

1 reference

Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury.

31 March 2020

1 reference

Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction

31 March 2020

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Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice

31 March 2020

1 reference

Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1718

1 reference

12 August 2017

1 reference

PubMed ID

15864271