(Q36146925)

12 August 2017

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title

Transcriptional networks in developing and mature B cells (English)

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12 August 2017

Patrick Matthias

1

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PubMed ID

15928681

12 August 2017

Antonius G Rolink

series ordinal

2

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12 August 2017

1 June 2005

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Nature Reviews Immunology

12 August 2017

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12 August 2017

5

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12 August 2017

497-508

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12 August 2017

6

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Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow

12 August 2017

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Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.

21 January 2018

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Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

21 January 2018

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Revising B cell receptors

21 January 2018

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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

21 January 2018

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Bipotential B-macrophage progenitors are present in adult bone marrow.

21 January 2018

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

21 January 2018

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PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors

21 January 2018

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

21 January 2018

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PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors

21 January 2018

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Analysis of gene expression and Ig transcription in PU.1/Spi-B-deficient progenitor B cell lines

21 January 2018

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Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.

21 January 2018

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Spi-B can functionally replace PU.1 in myeloid but not lymphoid development

21 January 2018

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Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

21 January 2018

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

21 January 2018

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The role of the Ikaros gene in lymphocyte development and homeostasis

21 January 2018

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Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

21 January 2018

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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

21 January 2018

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Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

21 January 2018

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

21 January 2018

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The Ikaros gene is required for the development of all lymphoid lineages

21 January 2018

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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

21 January 2018

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Defects in hemopoietic stem cell activity in Ikaros mutant mice

21 January 2018

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Ikaros is critical for B cell differentiation and function.

21 January 2018

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Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

21 January 2018

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Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

21 January 2018

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The CD8alpha gene locus is regulated by the Ikaros family of proteins.

21 January 2018

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

21 January 2018

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E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

21 January 2018

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Regulation of E2A gene expression in B-lymphocyte development

21 January 2018

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The helix-loop-helix gene E2A is required for B cell formation

21 January 2018

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A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex

21 January 2018

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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

21 January 2018

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Functional replacement of the mouse E2A gene with a human HEB cDNA.

21 January 2018

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Failure of B-cell differentiation in mice lacking the transcription factor EBF.

21 January 2018

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Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A

21 January 2018

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Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression

21 January 2018

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Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

21 January 2018

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EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

21 January 2018

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E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

21 January 2018

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Assembling a gene regulatory network for specification of the B cell fate

21 January 2018

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Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter

21 January 2018

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Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

21 January 2018

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Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

21 January 2018

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

21 January 2018

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Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

21 January 2018

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

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Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

21 January 2018

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Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones

21 January 2018

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Reversion of B cell commitment upon loss of Pax5 expression

21 January 2018

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Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

21 January 2018

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Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.

21 January 2018

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Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

21 January 2018

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Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes

21 January 2018

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Notch regulation of lymphocyte development and function.

21 January 2018

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Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.

21 January 2018

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Stepwise reprogramming of B cells into macrophages

21 January 2018

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Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

21 January 2018

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HMG box containing transcription factors in lymphocyte differentiation.

21 January 2018

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WNT signalling and haematopoiesis: a WNT-WNT situation

21 January 2018

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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

21 January 2018

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IRF family of transcription factors as regulators of host defense

21 January 2018

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Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

21 January 2018

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IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

21 January 2018

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Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice

21 January 2018

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Regulation of plasma-cell development

21 January 2018

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Regulation of BOB.1/OBF.1 stability by SIAH

21 January 2018

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The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

21 January 2018

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Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival

21 January 2018

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Lymphoid-specific transcription mediated by the conserved octamer site: who is doing what?

21 January 2018

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B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1.

21 January 2018

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OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes

21 January 2018

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Aiolos regulates B cell activation and maturation to effector state

21 January 2018

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The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development

21 January 2018

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Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.

21 January 2018

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BOB.1/OBF.1 deficiency affects marginal-zone B-cell compartment.

21 January 2018

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Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation.

21 January 2018

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B cell development and immunoglobulin transcription in Oct-1-deficient mice

21 January 2018

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

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21 January 2018

Signaling to NF-kappaB

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Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

21 January 2018

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Nuclear factor kappa B is required for the development of marginal zone B lymphocytes

21 January 2018

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The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

21 January 2018

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Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators.

21 January 2018

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Requirement for NF-kappaB in osteoclast and B-cell development

21 January 2018

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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

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Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

21 January 2018

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

21 January 2018

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PU.1/Spi-B regulation of c-rel is essential for mature B cell survival

21 January 2018

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A stepwise epigenetic process controls immunoglobulin allelic exclusion

21 January 2018

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B cell development pathways

21 January 2018

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

21 January 2018

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The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

21 January 2018

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B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

21 January 2018

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Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

21 January 2018

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Thymopoiesis independent of common lymphoid progenitors

31 March 2020

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VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

31 March 2020

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Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

31 March 2020

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Constitutive expression of the Id1 gene impairs mouse B cell development

31 March 2020

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EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains

31 March 2020

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

31 March 2020

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B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1

31 March 2020

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Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines

31 March 2020

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The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21

31 March 2020

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PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction

31 March 2020

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Circulating hematopoietic progenitors with T lineage potential

31 March 2020

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Essential role of Id2 in negative regulation of IgE class switching

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1633

1 reference

12 August 2017

1 reference

PubMed ID

15928681